TY - JOUR

T1 - Cohesion of Cortical Language Networks During Word Processing Is Predicted by a Common Polymorphism in the SETBP1 Gene

AU - Rakhlin, Natalia

AU - Landi, Nicole

AU - Lee, Maria

AU - Magnuson, James S.

AU - Naumova, Oxana Yu

AU - Ovchinnikova, Irina V.

AU - Grigorenko, Elena L.

PY - 2020

Y1 - 2020

N2 - The etiological mechanisms of the genetic underpinnings of developmental language disorder (DLD) are unknown, in part due to the behavioral heterogeneity of the disorder's manifestations. In this study, we explored an association between the SETBP1 gene (18q21.1), revealed in a genome-wide association study of DLD in a geographically isolated population, and brain network-based endophenotypes of functional intracortical coherence between major language-related brain areas. We analyzed electroencephalogram (EEG) data from thirty-nine children (twenty-three with, sixteen without DLD) aged 7.17–15.83 years acquired during an auditory picture–word matching paradigm. Variation at a single nucleotide polymorphism in the intronic region of the SETBP1 gene, rs8085464, explained 19% of the variance in intracortical network cohesion (p =.00478). This suggests that the development of these brain networks might be partially associated with the variation in SETBP1.

AB - The etiological mechanisms of the genetic underpinnings of developmental language disorder (DLD) are unknown, in part due to the behavioral heterogeneity of the disorder's manifestations. In this study, we explored an association between the SETBP1 gene (18q21.1), revealed in a genome-wide association study of DLD in a geographically isolated population, and brain network-based endophenotypes of functional intracortical coherence between major language-related brain areas. We analyzed electroencephalogram (EEG) data from thirty-nine children (twenty-three with, sixteen without DLD) aged 7.17–15.83 years acquired during an auditory picture–word matching paradigm. Variation at a single nucleotide polymorphism in the intronic region of the SETBP1 gene, rs8085464, explained 19% of the variance in intracortical network cohesion (p =.00478). This suggests that the development of these brain networks might be partially associated with the variation in SETBP1.

UR - http://www.scopus.com/inward/record.url?scp=85083949092&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/21674c4b-0cd1-3fa1-af44-2b012b2c25de/

U2 - 10.1002/cad.20331

DO - 10.1002/cad.20331

M3 - Article

C2 - 32324324

AN - SCOPUS:85083949092

VL - 2020

SP - 131

EP - 155

JO - New Directions for Child and Adolescent Development

JF - New Directions for Child and Adolescent Development

SN - 1520-3247

IS - 169

ER -