Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs. / Nerush, M.O.; Shevyrin, V.A.; Golushko, N.I.; Moskalenko, A.M.; Rosemberg, D.B.; De Abreu, M.S.; Yang, L.-E.; Galstyan, D.S.; Lim, L.W.; Demin, K.A.; Kalueff, A.V.
в: ACS Chemical Neuroscience, 15.10.2024.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs
AU - Nerush, M.O.
AU - Shevyrin, V.A.
AU - Golushko, N.I.
AU - Moskalenko, A.M.
AU - Rosemberg, D.B.
AU - De Abreu, M.S.
AU - Yang, L.-E.
AU - Galstyan, D.S.
AU - Lim, L.W.
AU - Demin, K.A.
AU - Kalueff, A.V.
N1 - Export Date: 27 October 2024 CODEN: ACNCD Сведения о финансировании: Saint Petersburg State University, SPbU, 95443748 Текст о финансировании 1: This research was supported by the Saint Petersburg State University budgetary funds (Pure ID: 95443748).
PY - 2024/10/15
Y1 - 2024/10/15
N2 - Antihistaminic drugs are widely used clinically and have long been primarily known for their use to treat severe allergic conditions caused by histamine release. Antihistaminic drugs also exert central nervous system (CNS) effects, acting as anxiolytics, hypnotics, and neuroleptics. However, these drugs also have multiple serious neuropharmacological side-effects, inducing delirium, hyperarousal, disorganized behavior, and hallucinations. Due to their robust CNS effects, antihistamines are also increasingly abused, with occasional overdoses and life-threatening toxicity. Here, we discuss chemical and neuropharmacological aspects of antihistaminic drugs in both human and animal (experimental) models and outline their current societal and mental health importance as neuroactive substances. © 2024 American Chemical Society.
AB - Antihistaminic drugs are widely used clinically and have long been primarily known for their use to treat severe allergic conditions caused by histamine release. Antihistaminic drugs also exert central nervous system (CNS) effects, acting as anxiolytics, hypnotics, and neuroleptics. However, these drugs also have multiple serious neuropharmacological side-effects, inducing delirium, hyperarousal, disorganized behavior, and hallucinations. Due to their robust CNS effects, antihistamines are also increasingly abused, with occasional overdoses and life-threatening toxicity. Here, we discuss chemical and neuropharmacological aspects of antihistaminic drugs in both human and animal (experimental) models and outline their current societal and mental health importance as neuroactive substances. © 2024 American Chemical Society.
KW - Animal models
KW - Anticholinergic activity
KW - Antihistamines
KW - Delirium
KW - Drug use and abuse
KW - First generation H1 antagonists
KW - Histamine
KW - Side effects
KW - antihistaminic agent
KW - histamine H1 receptor antagonist
KW - hypnotic agent
KW - animal model
KW - anticholinergic effect
KW - delirium
KW - drug therapy
KW - drug use
KW - hallucination
KW - histamine release
KW - human
KW - neurochemistry
KW - nonhuman
KW - pharmacology
KW - review
KW - side effect
KW - therapy
UR - https://www.mendeley.com/catalogue/6ea713fe-e396-37b3-b802-d18a083da988/
U2 - 10.1021/acschemneuro.4c00505
DO - 10.1021/acschemneuro.4c00505
M3 - статья
JO - ACS Chemical Neuroscience
JF - ACS Chemical Neuroscience
SN - 1948-7193
ER -
ID: 126462398