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Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs. / Nerush, M.O.; Shevyrin, V.A.; Golushko, N.I.; Moskalenko, A.M.; Rosemberg, D.B.; De Abreu, M.S.; Yang, L.-E.; Galstyan, D.S.; Lim, L.W.; Demin, K.A.; Kalueff, A.V.

In: ACS Chemical Neuroscience, Vol. 15, No. 21, 06.11.2024, p. 3848–3862.

Research output: Contribution to journal › Article › peer-review

Harvard

Nerush, MO, Shevyrin, VA, Golushko, NI, Moskalenko, AM, Rosemberg, DB, De Abreu, MS, Yang, L-E, Galstyan, DS, Lim, LW, Demin, KA & Kalueff, AV 2024, 'Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs', ACS Chemical Neuroscience, vol. 15, no. 21, pp. 3848–3862. https://doi.org/10.1021/acschemneuro.4c00505

APA

Nerush, M. O., Shevyrin, V. A., Golushko, N. I., Moskalenko, A. M., Rosemberg, D. B., De Abreu, M. S., Yang, L-E., Galstyan, D. S., Lim, L. W., Demin, K. A., & Kalueff, A. V. (2024). Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs. ACS Chemical Neuroscience, 15(21), 3848–3862. https://doi.org/10.1021/acschemneuro.4c00505

Vancouver

Nerush MO, Shevyrin VA, Golushko NI, Moskalenko AM, Rosemberg DB, De Abreu MS et al. Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs. ACS Chemical Neuroscience. 2024 Nov 6;15(21):3848–3862. https://doi.org/10.1021/acschemneuro.4c00505

Author

Nerush, M.O. ; Shevyrin, V.A. ; Golushko, N.I. ; Moskalenko, A.M. ; Rosemberg, D.B. ; De Abreu, M.S. ; Yang, L.-E. ; Galstyan, D.S. ; Lim, L.W. ; Demin, K.A. ; Kalueff, A.V. / Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs. In: ACS Chemical Neuroscience. 2024 ; Vol. 15, No. 21. pp. 3848–3862.

BibTeX

@article{15156033f9ce468f9c0d80620aa92c0c,
title = "Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs",
abstract = "Antihistaminic drugs are widely used clinically and have long been primarily known for their use to treat severe allergic conditions caused by histamine release. Antihistaminic drugs also exert central nervous system (CNS) effects, acting as anxiolytics, hypnotics, and neuroleptics. However, these drugs also have multiple serious neuropharmacological side-effects, inducing delirium, hyperarousal, disorganized behavior, and hallucinations. Due to their robust CNS effects, antihistamines are also increasingly abused, with occasional overdoses and life-threatening toxicity. Here, we discuss chemical and neuropharmacological aspects of antihistaminic drugs in both human and animal (experimental) models and outline their current societal and mental health importance as neuroactive substances. {\textcopyright} 2024 American Chemical Society.",
keywords = "Animal models, Anticholinergic activity, Antihistamines, Delirium, Drug use and abuse, First generation H1 antagonists, Histamine, Side effects, antihistaminic agent, histamine H1 receptor antagonist, hypnotic agent, animal model, anticholinergic effect, delirium, drug therapy, drug use, hallucination, histamine release, human, neurochemistry, nonhuman, pharmacology, review, side effect, therapy",
author = "M.O. Nerush and V.A. Shevyrin and N.I. Golushko and A.M. Moskalenko and D.B. Rosemberg and {De Abreu}, M.S. and L.-E. Yang and D.S. Galstyan and L.W. Lim and K.A. Demin and A.V. Kalueff",
note = "Export Date: 27 October 2024 CODEN: ACNCD Сведения о финансировании: Saint Petersburg State University, SPbU, 95443748 Текст о финансировании 1: This research was supported by the Saint Petersburg State University budgetary funds (Pure ID: 95443748).",
year = "2024",
month = nov,
day = "6",
doi = "10.1021/acschemneuro.4c00505",
language = "Английский",
volume = "15",
pages = "3848–3862",
journal = "ACS Chemical Neuroscience",
issn = "1948-7193",
publisher = "American Chemical Society",
number = "21",

}

RIS

TY - JOUR

T1 - Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs

AU - Nerush, M.O.

AU - Shevyrin, V.A.

AU - Golushko, N.I.

AU - Moskalenko, A.M.

AU - Rosemberg, D.B.

AU - De Abreu, M.S.

AU - Yang, L.-E.

AU - Galstyan, D.S.

AU - Lim, L.W.

AU - Demin, K.A.

AU - Kalueff, A.V.

N1 - Export Date: 27 October 2024 CODEN: ACNCD Сведения о финансировании: Saint Petersburg State University, SPbU, 95443748 Текст о финансировании 1: This research was supported by the Saint Petersburg State University budgetary funds (Pure ID: 95443748).

PY - 2024/11/6

Y1 - 2024/11/6

N2 - Antihistaminic drugs are widely used clinically and have long been primarily known for their use to treat severe allergic conditions caused by histamine release. Antihistaminic drugs also exert central nervous system (CNS) effects, acting as anxiolytics, hypnotics, and neuroleptics. However, these drugs also have multiple serious neuropharmacological side-effects, inducing delirium, hyperarousal, disorganized behavior, and hallucinations. Due to their robust CNS effects, antihistamines are also increasingly abused, with occasional overdoses and life-threatening toxicity. Here, we discuss chemical and neuropharmacological aspects of antihistaminic drugs in both human and animal (experimental) models and outline their current societal and mental health importance as neuroactive substances. © 2024 American Chemical Society.

AB - Antihistaminic drugs are widely used clinically and have long been primarily known for their use to treat severe allergic conditions caused by histamine release. Antihistaminic drugs also exert central nervous system (CNS) effects, acting as anxiolytics, hypnotics, and neuroleptics. However, these drugs also have multiple serious neuropharmacological side-effects, inducing delirium, hyperarousal, disorganized behavior, and hallucinations. Due to their robust CNS effects, antihistamines are also increasingly abused, with occasional overdoses and life-threatening toxicity. Here, we discuss chemical and neuropharmacological aspects of antihistaminic drugs in both human and animal (experimental) models and outline their current societal and mental health importance as neuroactive substances. © 2024 American Chemical Society.

KW - Animal models

KW - Anticholinergic activity

KW - Antihistamines

KW - Delirium

KW - Drug use and abuse

KW - First generation H1 antagonists

KW - Histamine

KW - Side effects

KW - antihistaminic agent

KW - histamine H1 receptor antagonist

KW - hypnotic agent

KW - animal model

KW - anticholinergic effect

KW - delirium

KW - drug therapy

KW - drug use

KW - hallucination

KW - histamine release

KW - human

KW - neurochemistry

KW - nonhuman

KW - pharmacology

KW - review

KW - side effect

KW - therapy

UR - https://www.mendeley.com/catalogue/6ea713fe-e396-37b3-b802-d18a083da988/

U2 - 10.1021/acschemneuro.4c00505

DO - 10.1021/acschemneuro.4c00505

M3 - статья

VL - 15

SP - 3848

EP - 3862

JO - ACS Chemical Neuroscience

JF - ACS Chemical Neuroscience

SN - 1948-7193

IS - 21

ER -

ID: 126462398