Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
C60 adduct with L-arginine as a promising nanomaterial for treating cerebral ischemic stroke. / Kukaliia, Olegi N.; Ageev, Sergei V.; Petrov, Andrey V.; Kirik, Olga V.; Korzhevskii, Dmitrii E.; Meshcheriakov, Anatolii A.; Jakovleva, Anastasia A.; Poliakova, Liudmila S.; Novikova, Tatiana A.; Kolpakova, Maria E.; Vlasov, Timur D.; Molchanov, Oleg E.; Maistrenko, Dmitriy N.; Murin, Igor V.; Sharoyko, Vladimir V.; Semenov, Konstantin N.
в: Nanomedicine: Nanotechnology, Biology, and Medicine, Том 53, 102698, 01.09.2023.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - C60 adduct with L-arginine as a promising nanomaterial for treating cerebral ischemic stroke
AU - Kukaliia, Olegi N.
AU - Ageev, Sergei V.
AU - Petrov, Andrey V.
AU - Kirik, Olga V.
AU - Korzhevskii, Dmitrii E.
AU - Meshcheriakov, Anatolii A.
AU - Jakovleva, Anastasia A.
AU - Poliakova, Liudmila S.
AU - Novikova, Tatiana A.
AU - Kolpakova, Maria E.
AU - Vlasov, Timur D.
AU - Molchanov, Oleg E.
AU - Maistrenko, Dmitriy N.
AU - Murin, Igor V.
AU - Sharoyko, Vladimir V.
AU - Semenov, Konstantin N.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - The work aimed to investigate the biocompatibility and biological activity of the water-soluble fullerene adduct C60-Arg. It was found that the material is haemocompatible, is not cyto- and genotoxic, possesses pronounced antioxidant activity. Additionally, this paper outlines the direction of application of water-soluble fullerene adducts in the creation of neuroprotectors. It has been suggested that a putative mechanism of the protective action of the C60-Arg adduct is associated with its antioxidant properties, the ability to penetrate the blood-brain barrier, and release nitrogen monoxide as a result of the catabolism of L-arginine residues, which promote vascular relaxation. The action of the C60-Arg adduct was compared with the action of such an antioxidant as Edaravone, which is approved in Japan for the treatment of ischemic and haemorrhagic strokes.
AB - The work aimed to investigate the biocompatibility and biological activity of the water-soluble fullerene adduct C60-Arg. It was found that the material is haemocompatible, is not cyto- and genotoxic, possesses pronounced antioxidant activity. Additionally, this paper outlines the direction of application of water-soluble fullerene adducts in the creation of neuroprotectors. It has been suggested that a putative mechanism of the protective action of the C60-Arg adduct is associated with its antioxidant properties, the ability to penetrate the blood-brain barrier, and release nitrogen monoxide as a result of the catabolism of L-arginine residues, which promote vascular relaxation. The action of the C60-Arg adduct was compared with the action of such an antioxidant as Edaravone, which is approved in Japan for the treatment of ischemic and haemorrhagic strokes.
UR - https://www.mendeley.com/catalogue/94cf9477-a956-3f14-81c9-5947e66060dc/
U2 - 10.1016/j.nano.2023.102698
DO - 10.1016/j.nano.2023.102698
M3 - Article
VL - 53
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
SN - 1549-9634
M1 - 102698
ER -
ID: 113663014