TY - JOUR

T1 - Biomonitoring of 20 trace elements in blood and urine of occupationally exposed workers by sector field inductively coupled plasma mass spectrometry

AU - Ivanenko, N.B.

AU - Ivanenko, A.A.

AU - Solovyev, N.D.

AU - Zeimal, A.E.

AU - Navolotskii, D.V.

AU - Drobyshev, E.J.

PY - 2013

Y1 - 2013

N2 - A sector field inductively coupled mass spectrometry method for the determination of Ag, Al, As, Ba, Be, Cd, Co, Cr, Cs, Cu, Fe, Mn, Ni, Pb, Se, Sr, Tl, U, V and Zn in whole blood and urine was designed. Microwave-assisted digestion with concentrated nitric acid was used for blood samples. Urine samples were analyzed after 1/50 (v/v) dilution with 5% (v/v) nitric acid. For beryllium the necessity of medium resolution mode (R=4000) was shown. Method validation was performed using blood and urine reference materials and by analyzing of spiked samples. For the designed method relative standard deviation (RSD) for the concentration range 0.01 – 1.0 μg/L was 5 – 10%. RSD did not exceed 3% when trace elements concentrations were above 1.0 μg/L. Method detection limits (3σ): Ag 0.7 ng/L, Al 16 ng/L, As 3.4 ng/L, Ba 0.02 ng/L, Be 1.5 ng/L, Cd 7.7 ng/L, Co 1.0 ng/L, Cr 2.8 ng/L, Cs 9.8 ng/L, Cu 27 ng/L, Fe 1.1 ng/L, Mn 1.8 ng/L, Ni 17 ng/L, Pb 13 ng/L, Se 0.07 ng/L, Sr 5.7 ng/L, Tl 0.2 ng/L, U 0.1 ng/L, V 0.7 ng/L an

AB - A sector field inductively coupled mass spectrometry method for the determination of Ag, Al, As, Ba, Be, Cd, Co, Cr, Cs, Cu, Fe, Mn, Ni, Pb, Se, Sr, Tl, U, V and Zn in whole blood and urine was designed. Microwave-assisted digestion with concentrated nitric acid was used for blood samples. Urine samples were analyzed after 1/50 (v/v) dilution with 5% (v/v) nitric acid. For beryllium the necessity of medium resolution mode (R=4000) was shown. Method validation was performed using blood and urine reference materials and by analyzing of spiked samples. For the designed method relative standard deviation (RSD) for the concentration range 0.01 – 1.0 μg/L was 5 – 10%. RSD did not exceed 3% when trace elements concentrations were above 1.0 μg/L. Method detection limits (3σ): Ag 0.7 ng/L, Al 16 ng/L, As 3.4 ng/L, Ba 0.02 ng/L, Be 1.5 ng/L, Cd 7.7 ng/L, Co 1.0 ng/L, Cr 2.8 ng/L, Cs 9.8 ng/L, Cu 27 ng/L, Fe 1.1 ng/L, Mn 1.8 ng/L, Ni 17 ng/L, Pb 13 ng/L, Se 0.07 ng/L, Sr 5.7 ng/L, Tl 0.2 ng/L, U 0.1 ng/L, V 0.7 ng/L an

KW - Biomonitoring

KW - Blood

KW - Urine

KW - Beryllium

KW - Trace elements

KW - Sector field inductively coupled mass spectrometry

KW - Inductively coupled plasma optical emission spectrometry

U2 - 10.1016/j.talanta.2013.07.079

DO - 10.1016/j.talanta.2013.07.079

M3 - Article

VL - 116

SP - 764

EP - 769

JO - Talanta

JF - Talanta

SN - 0039-9140

ER -