Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Biocompatibility and bioactivity study of a cytostatic drug belonging to the group of alkylating agents of the triazine derivative class. / Mikolaichuk, Olga V.; Sharoyko, Vladimir V.; Popova, Elena A.; Protas, Alexandra V.; Fonin, Alexander V.; Vasina, Lubov V.; Anufrikov, Yurii A.; Luttsev, Mikhail D.; Nashchekina, Iuliia A.; Malkova, Anna M.; Tochilnikov, Grigorii V.; Ageev, Sergei V.; Semenov, Konstantin N.
в: Journal of Molecular Liquids, Том 343, 117630, 01.12.2021.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Biocompatibility and bioactivity study of a cytostatic drug belonging to the group of alkylating agents of the triazine derivative class
AU - Mikolaichuk, Olga V.
AU - Sharoyko, Vladimir V.
AU - Popova, Elena A.
AU - Protas, Alexandra V.
AU - Fonin, Alexander V.
AU - Vasina, Lubov V.
AU - Anufrikov, Yurii A.
AU - Luttsev, Mikhail D.
AU - Nashchekina, Iuliia A.
AU - Malkova, Anna M.
AU - Tochilnikov, Grigorii V.
AU - Ageev, Sergei V.
AU - Semenov, Konstantin N.
N1 - Publisher Copyright: © 2021 Elsevier B.V.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - The article describes the study of biocompatibility and bioactivity of a cytostatic agent [5-[[4,6-bis(aziridin-1-yl)-1,3,5-triazin-2-yl]amino]-2,2-dimethyl-1,3-dioxan-5-yl]methanol (substance (a)). The compound was characterised by means of 1H and 13C NMR spectroscopy, IR spectroscopy, mass spectrometry. Biomedicinal investigations included haemocompatibility studies (spontaneous haemolysis, platelet aggregation, plasma-coagulation haemostasis, binding with human serum albumin and DNA); determination of antioxidant properties (reaction with 2,2-diphenyl-1-picrylhydrazyl, photo-induced haemolysis, photodynamic properties, NO-radical uptake); genotoxicity, as well as cytotoxicity using HEK-293, A549, PA-1, T98G, SK-HEP-1, PANC-1 cell lines. The article shows two possible mechanisms of the cytostatic action of the substance (a): due to its antioxidant activity and the possibility of the formation of adducts with DNA.
AB - The article describes the study of biocompatibility and bioactivity of a cytostatic agent [5-[[4,6-bis(aziridin-1-yl)-1,3,5-triazin-2-yl]amino]-2,2-dimethyl-1,3-dioxan-5-yl]methanol (substance (a)). The compound was characterised by means of 1H and 13C NMR spectroscopy, IR spectroscopy, mass spectrometry. Biomedicinal investigations included haemocompatibility studies (spontaneous haemolysis, platelet aggregation, plasma-coagulation haemostasis, binding with human serum albumin and DNA); determination of antioxidant properties (reaction with 2,2-diphenyl-1-picrylhydrazyl, photo-induced haemolysis, photodynamic properties, NO-radical uptake); genotoxicity, as well as cytotoxicity using HEK-293, A549, PA-1, T98G, SK-HEP-1, PANC-1 cell lines. The article shows two possible mechanisms of the cytostatic action of the substance (a): due to its antioxidant activity and the possibility of the formation of adducts with DNA.
KW - Bioactivity; Biocompatibility; Cytostatic Agent; DPPH; Haemolysis; HSA
KW - Cytostatic Agent
KW - Bioactivity
KW - Biocompatibility
KW - Haemolysis
KW - DPPH
KW - HSA
KW - PHOTODYNAMIC THERAPY
KW - ANTITUMOR-ACTIVITY
KW - CANCER
KW - CELLS
KW - DNA
KW - CHEMOTHERAPY
KW - TITRATION
KW - DIOXADET
UR - http://www.scopus.com/inward/record.url?scp=85115887273&partnerID=8YFLogxK
U2 - 10.1016/j.molliq.2021.117630
DO - 10.1016/j.molliq.2021.117630
M3 - Article
AN - SCOPUS:85115887273
VL - 343
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
SN - 0167-7322
M1 - 117630
ER -
ID: 87328047