Biocompatibility and bioactivity study of a cytostatic drug belonging to the group of alkylating agents of the triazine derivative class

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Biocompatibility and bioactivity study of a cytostatic drug belonging to the group of alkylating agents of the triazine derivative class. / Mikolaichuk, Olga V.; Sharoyko, Vladimir V.; Popova, Elena A.; Protas, Alexandra V.; Fonin, Alexander V.; Vasina, Lubov V.; Anufrikov, Yurii A.; Luttsev, Mikhail D.; Nashchekina, Iuliia A.; Malkova, Anna M.; Tochilnikov, Grigorii V.; Ageev, Sergei V.; Semenov, Konstantin N.

In: Journal of Molecular Liquids, Vol. 343, 117630, 01.12.2021.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{d9df527b44e04648a79b7b2b120dc494,

title = "Biocompatibility and bioactivity study of a cytostatic drug belonging to the group of alkylating agents of the triazine derivative class",

abstract = "The article describes the study of biocompatibility and bioactivity of a cytostatic agent [5-[[4,6-bis(aziridin-1-yl)-1,3,5-triazin-2-yl]amino]-2,2-dimethyl-1,3-dioxan-5-yl]methanol (substance (a)). The compound was characterised by means of 1H and 13C NMR spectroscopy, IR spectroscopy, mass spectrometry. Biomedicinal investigations included haemocompatibility studies (spontaneous haemolysis, platelet aggregation, plasma-coagulation haemostasis, binding with human serum albumin and DNA); determination of antioxidant properties (reaction with 2,2-diphenyl-1-picrylhydrazyl, photo-induced haemolysis, photodynamic properties, NO-radical uptake); genotoxicity, as well as cytotoxicity using HEK-293, A549, PA-1, T98G, SK-HEP-1, PANC-1 cell lines. The article shows two possible mechanisms of the cytostatic action of the substance (a): due to its antioxidant activity and the possibility of the formation of adducts with DNA.",

keywords = "Bioactivity; Biocompatibility; Cytostatic Agent; DPPH; Haemolysis; HSA, Cytostatic Agent, Bioactivity, Biocompatibility, Haemolysis, DPPH, HSA, PHOTODYNAMIC THERAPY, ANTITUMOR-ACTIVITY, CANCER, CELLS, DNA, CHEMOTHERAPY, TITRATION, DIOXADET",

author = "Mikolaichuk, {Olga V.} and Sharoyko, {Vladimir V.} and Popova, {Elena A.} and Protas, {Alexandra V.} and Fonin, {Alexander V.} and Vasina, {Lubov V.} and Anufrikov, {Yurii A.} and Luttsev, {Mikhail D.} and Nashchekina, {Iuliia A.} and Malkova, {Anna M.} and Tochilnikov, {Grigorii V.} and Ageev, {Sergei V.} and Semenov, {Konstantin N.}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = dec,

day = "1",

doi = "10.1016/j.molliq.2021.117630",

language = "English",

volume = "343",

journal = "Journal of Molecular Liquids",

issn = "0167-7322",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Biocompatibility and bioactivity study of a cytostatic drug belonging to the group of alkylating agents of the triazine derivative class

AU - Mikolaichuk, Olga V.

AU - Sharoyko, Vladimir V.

AU - Popova, Elena A.

AU - Protas, Alexandra V.

AU - Fonin, Alexander V.

AU - Vasina, Lubov V.

AU - Anufrikov, Yurii A.

AU - Luttsev, Mikhail D.

AU - Nashchekina, Iuliia A.

AU - Malkova, Anna M.

AU - Tochilnikov, Grigorii V.

AU - Ageev, Sergei V.

AU - Semenov, Konstantin N.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - The article describes the study of biocompatibility and bioactivity of a cytostatic agent [5-[[4,6-bis(aziridin-1-yl)-1,3,5-triazin-2-yl]amino]-2,2-dimethyl-1,3-dioxan-5-yl]methanol (substance (a)). The compound was characterised by means of 1H and 13C NMR spectroscopy, IR spectroscopy, mass spectrometry. Biomedicinal investigations included haemocompatibility studies (spontaneous haemolysis, platelet aggregation, plasma-coagulation haemostasis, binding with human serum albumin and DNA); determination of antioxidant properties (reaction with 2,2-diphenyl-1-picrylhydrazyl, photo-induced haemolysis, photodynamic properties, NO-radical uptake); genotoxicity, as well as cytotoxicity using HEK-293, A549, PA-1, T98G, SK-HEP-1, PANC-1 cell lines. The article shows two possible mechanisms of the cytostatic action of the substance (a): due to its antioxidant activity and the possibility of the formation of adducts with DNA.

AB - The article describes the study of biocompatibility and bioactivity of a cytostatic agent [5-[[4,6-bis(aziridin-1-yl)-1,3,5-triazin-2-yl]amino]-2,2-dimethyl-1,3-dioxan-5-yl]methanol (substance (a)). The compound was characterised by means of 1H and 13C NMR spectroscopy, IR spectroscopy, mass spectrometry. Biomedicinal investigations included haemocompatibility studies (spontaneous haemolysis, platelet aggregation, plasma-coagulation haemostasis, binding with human serum albumin and DNA); determination of antioxidant properties (reaction with 2,2-diphenyl-1-picrylhydrazyl, photo-induced haemolysis, photodynamic properties, NO-radical uptake); genotoxicity, as well as cytotoxicity using HEK-293, A549, PA-1, T98G, SK-HEP-1, PANC-1 cell lines. The article shows two possible mechanisms of the cytostatic action of the substance (a): due to its antioxidant activity and the possibility of the formation of adducts with DNA.

KW - Bioactivity; Biocompatibility; Cytostatic Agent; DPPH; Haemolysis; HSA

KW - Cytostatic Agent

KW - Bioactivity

KW - Biocompatibility

KW - Haemolysis

KW - DPPH

KW - HSA

KW - PHOTODYNAMIC THERAPY

KW - ANTITUMOR-ACTIVITY

KW - CANCER

KW - CELLS

KW - DNA

KW - CHEMOTHERAPY

KW - TITRATION

KW - DIOXADET

UR - http://www.scopus.com/inward/record.url?scp=85115887273&partnerID=8YFLogxK

U2 - 10.1016/j.molliq.2021.117630

DO - 10.1016/j.molliq.2021.117630

M3 - Article

AN - SCOPUS:85115887273

VL - 343

JO - Journal of Molecular Liquids

JF - Journal of Molecular Liquids

SN - 0167-7322

M1 - 117630

ER -

ID: 87328047