Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Biochemical and Morphological Parameters of Inbred/Outbred Lines and DBCB Tetrahybrid Mouse in High-Sugar In Vivo Model of Metabolic Syndrome. / Apryatin, S. A.; Mzhel’skaya, K. V.; Trusov, N. V.; Balakina, A. S.; Soto, Kh S.; Beketova, N. A.; Kosheleva, O. V.; Gmoshinskii, I. V.; Nikityuk, D. B.
в: Bulletin of Experimental Biology and Medicine, Том 166, № 1, 01.11.2018, стр. 96-101.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Biochemical and Morphological Parameters of Inbred/Outbred Lines and DBCB Tetrahybrid Mouse in High-Sugar In Vivo Model of Metabolic Syndrome
AU - Apryatin, S. A.
AU - Mzhel’skaya, K. V.
AU - Trusov, N. V.
AU - Balakina, A. S.
AU - Soto, Kh S.
AU - Beketova, N. A.
AU - Kosheleva, O. V.
AU - Gmoshinskii, I. V.
AU - Nikityuk, D. B.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Integral, biochemical, and morphological parameters and concentrations of vitamins, particularly lipid soluble vitamins, were analyzed in female mice of inbred DBA/2J line, outbred ICR-1 (CD-1) line, and DBCB tetrahybrid mice on the in vivo model of metabolic syndrome induced by consumption of 30% sucrose for 2 days. In contrast to inbred and outbred lines, DBCB tetrahybrid mice developed abdominal obesity, hypercholesterolemia, and pronounced morphological picture of fatty liver disease. The lipid-coupled transport of vitamin E to the liver is also enhanced in these animals, which compensated decreased supply of vitamin E to the liver under conditions of high-sugar ration. The observed interstrain differences can be related to genetic features of the used mouse lines and DBCB tetrahybrid mice and require further genomic, transcriptomic, proteomic, and morphological studies. The results of the study based on the in vivo model of metabolic syndrome allow identifying the key biomarkers for complex diagnostics and prognosis of metabolic syndrome complications, such as nonalcoholic steatosis of the liver.
AB - Integral, biochemical, and morphological parameters and concentrations of vitamins, particularly lipid soluble vitamins, were analyzed in female mice of inbred DBA/2J line, outbred ICR-1 (CD-1) line, and DBCB tetrahybrid mice on the in vivo model of metabolic syndrome induced by consumption of 30% sucrose for 2 days. In contrast to inbred and outbred lines, DBCB tetrahybrid mice developed abdominal obesity, hypercholesterolemia, and pronounced morphological picture of fatty liver disease. The lipid-coupled transport of vitamin E to the liver is also enhanced in these animals, which compensated decreased supply of vitamin E to the liver under conditions of high-sugar ration. The observed interstrain differences can be related to genetic features of the used mouse lines and DBCB tetrahybrid mice and require further genomic, transcriptomic, proteomic, and morphological studies. The results of the study based on the in vivo model of metabolic syndrome allow identifying the key biomarkers for complex diagnostics and prognosis of metabolic syndrome complications, such as nonalcoholic steatosis of the liver.
KW - in vivo model
KW - metabolic syndrome
KW - mice
KW - sucrose
KW - tetrahybrid
UR - http://www.scopus.com/inward/record.url?scp=85056434679&partnerID=8YFLogxK
U2 - 10.1007/s10517-018-4296-2
DO - 10.1007/s10517-018-4296-2
M3 - Article
C2 - 30417297
AN - SCOPUS:85056434679
VL - 166
SP - 96
EP - 101
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 1
ER -
ID: 115017653