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Biochemical and Morphological Parameters of Inbred/Outbred Lines and DBCB Tetrahybrid Mouse in High-Sugar In Vivo Model of Metabolic Syndrome. / Apryatin, S. A.; Mzhel’skaya, K. V.; Trusov, N. V.; Balakina, A. S.; Soto, Kh S.; Beketova, N. A.; Kosheleva, O. V.; Gmoshinskii, I. V.; Nikityuk, D. B.

In: Bulletin of Experimental Biology and Medicine, Vol. 166, No. 1, 01.11.2018, p. 96-101.

Research output: Contribution to journal › Article › peer-review

Harvard

Apryatin, SA, Mzhel’skaya, KV, Trusov, NV, Balakina, AS, Soto, KS, Beketova, NA, Kosheleva, OV, Gmoshinskii, IV & Nikityuk, DB 2018, 'Biochemical and Morphological Parameters of Inbred/Outbred Lines and DBCB Tetrahybrid Mouse in High-Sugar In Vivo Model of Metabolic Syndrome', Bulletin of Experimental Biology and Medicine, vol. 166, no. 1, pp. 96-101. https://doi.org/10.1007/s10517-018-4296-2

APA

Apryatin, S. A., Mzhel’skaya, K. V., Trusov, N. V., Balakina, A. S., Soto, K. S., Beketova, N. A., Kosheleva, O. V., Gmoshinskii, I. V., & Nikityuk, D. B. (2018). Biochemical and Morphological Parameters of Inbred/Outbred Lines and DBCB Tetrahybrid Mouse in High-Sugar In Vivo Model of Metabolic Syndrome. Bulletin of Experimental Biology and Medicine, 166(1), 96-101. https://doi.org/10.1007/s10517-018-4296-2

Vancouver

Apryatin SA, Mzhel’skaya KV, Trusov NV, Balakina AS, Soto KS, Beketova NA et al. Biochemical and Morphological Parameters of Inbred/Outbred Lines and DBCB Tetrahybrid Mouse in High-Sugar In Vivo Model of Metabolic Syndrome. Bulletin of Experimental Biology and Medicine. 2018 Nov 1;166(1):96-101. https://doi.org/10.1007/s10517-018-4296-2

Author

Apryatin, S. A. ; Mzhel’skaya, K. V. ; Trusov, N. V. ; Balakina, A. S. ; Soto, Kh S. ; Beketova, N. A. ; Kosheleva, O. V. ; Gmoshinskii, I. V. ; Nikityuk, D. B. / Biochemical and Morphological Parameters of Inbred/Outbred Lines and DBCB Tetrahybrid Mouse in High-Sugar In Vivo Model of Metabolic Syndrome. In: Bulletin of Experimental Biology and Medicine. 2018 ; Vol. 166, No. 1. pp. 96-101.

BibTeX

@article{ccc7947c8b324ab583e4fb026c754a57,
title = "Biochemical and Morphological Parameters of Inbred/Outbred Lines and DBCB Tetrahybrid Mouse in High-Sugar In Vivo Model of Metabolic Syndrome",
abstract = "Integral, biochemical, and morphological parameters and concentrations of vitamins, particularly lipid soluble vitamins, were analyzed in female mice of inbred DBA/2J line, outbred ICR-1 (CD-1) line, and DBCB tetrahybrid mice on the in vivo model of metabolic syndrome induced by consumption of 30% sucrose for 2 days. In contrast to inbred and outbred lines, DBCB tetrahybrid mice developed abdominal obesity, hypercholesterolemia, and pronounced morphological picture of fatty liver disease. The lipid-coupled transport of vitamin E to the liver is also enhanced in these animals, which compensated decreased supply of vitamin E to the liver under conditions of high-sugar ration. The observed interstrain differences can be related to genetic features of the used mouse lines and DBCB tetrahybrid mice and require further genomic, transcriptomic, proteomic, and morphological studies. The results of the study based on the in vivo model of metabolic syndrome allow identifying the key biomarkers for complex diagnostics and prognosis of metabolic syndrome complications, such as nonalcoholic steatosis of the liver.",
keywords = "in vivo model, metabolic syndrome, mice, sucrose, tetrahybrid",
author = "Apryatin, {S. A.} and Mzhel{\textquoteright}skaya, {K. V.} and Trusov, {N. V.} and Balakina, {A. S.} and Soto, {Kh S.} and Beketova, {N. A.} and Kosheleva, {O. V.} and Gmoshinskii, {I. V.} and Nikityuk, {D. B.}",
year = "2018",
month = nov,
day = "1",
doi = "10.1007/s10517-018-4296-2",
language = "English",
volume = "166",
pages = "96--101",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer Nature",
number = "1",

}

RIS

TY - JOUR

T1 - Biochemical and Morphological Parameters of Inbred/Outbred Lines and DBCB Tetrahybrid Mouse in High-Sugar In Vivo Model of Metabolic Syndrome

AU - Apryatin, S. A.

AU - Mzhel’skaya, K. V.

AU - Trusov, N. V.

AU - Balakina, A. S.

AU - Soto, Kh S.

AU - Beketova, N. A.

AU - Kosheleva, O. V.

AU - Gmoshinskii, I. V.

AU - Nikityuk, D. B.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Integral, biochemical, and morphological parameters and concentrations of vitamins, particularly lipid soluble vitamins, were analyzed in female mice of inbred DBA/2J line, outbred ICR-1 (CD-1) line, and DBCB tetrahybrid mice on the in vivo model of metabolic syndrome induced by consumption of 30% sucrose for 2 days. In contrast to inbred and outbred lines, DBCB tetrahybrid mice developed abdominal obesity, hypercholesterolemia, and pronounced morphological picture of fatty liver disease. The lipid-coupled transport of vitamin E to the liver is also enhanced in these animals, which compensated decreased supply of vitamin E to the liver under conditions of high-sugar ration. The observed interstrain differences can be related to genetic features of the used mouse lines and DBCB tetrahybrid mice and require further genomic, transcriptomic, proteomic, and morphological studies. The results of the study based on the in vivo model of metabolic syndrome allow identifying the key biomarkers for complex diagnostics and prognosis of metabolic syndrome complications, such as nonalcoholic steatosis of the liver.

AB - Integral, biochemical, and morphological parameters and concentrations of vitamins, particularly lipid soluble vitamins, were analyzed in female mice of inbred DBA/2J line, outbred ICR-1 (CD-1) line, and DBCB tetrahybrid mice on the in vivo model of metabolic syndrome induced by consumption of 30% sucrose for 2 days. In contrast to inbred and outbred lines, DBCB tetrahybrid mice developed abdominal obesity, hypercholesterolemia, and pronounced morphological picture of fatty liver disease. The lipid-coupled transport of vitamin E to the liver is also enhanced in these animals, which compensated decreased supply of vitamin E to the liver under conditions of high-sugar ration. The observed interstrain differences can be related to genetic features of the used mouse lines and DBCB tetrahybrid mice and require further genomic, transcriptomic, proteomic, and morphological studies. The results of the study based on the in vivo model of metabolic syndrome allow identifying the key biomarkers for complex diagnostics and prognosis of metabolic syndrome complications, such as nonalcoholic steatosis of the liver.

KW - in vivo model

KW - metabolic syndrome

KW - mice

KW - sucrose

KW - tetrahybrid

UR - http://www.scopus.com/inward/record.url?scp=85056434679&partnerID=8YFLogxK

U2 - 10.1007/s10517-018-4296-2

DO - 10.1007/s10517-018-4296-2

M3 - Article

C2 - 30417297

AN - SCOPUS:85056434679

VL - 166

SP - 96

EP - 101

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -

ID: 115017653