Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
BDNF Val66Met and cognition : All, none, or some? A meta-analysis of the genetic association. / Mandelman, S. D.; Grigorenko, E. L.
в: Genes, Brain and Behavior, Том 11, № 2, 03.2012, стр. 127-136.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - BDNF Val66Met and cognition
T2 - All, none, or some? A meta-analysis of the genetic association
AU - Mandelman, S. D.
AU - Grigorenko, E. L.
PY - 2012/3
Y1 - 2012/3
N2 - The Val66Met, G196A (rs6265) polymorphism in the brain-derived neurotrophic factor gene, BDNF, located at 11p13, has been associated with a wide range of cognitive functions. Yet, the pattern of results is complex and conflicting. In this study, we conducted a meta-analysis that included 23 publications containing 31 independent samples comprised of 7095 individuals. The phenotypes that were examined in this analysis covered a wide variety of cognitive functions and included indicators of general cognitive ability, memory, executive function, visual processing skills and cognitive fluency. The meta-analysis did not establish significant genetic associations between the Val66Met polymorphism and any of the phenotypes that were included.
AB - The Val66Met, G196A (rs6265) polymorphism in the brain-derived neurotrophic factor gene, BDNF, located at 11p13, has been associated with a wide range of cognitive functions. Yet, the pattern of results is complex and conflicting. In this study, we conducted a meta-analysis that included 23 publications containing 31 independent samples comprised of 7095 individuals. The phenotypes that were examined in this analysis covered a wide variety of cognitive functions and included indicators of general cognitive ability, memory, executive function, visual processing skills and cognitive fluency. The meta-analysis did not establish significant genetic associations between the Val66Met polymorphism and any of the phenotypes that were included.
KW - BDNF
KW - Cognition
KW - Cognitive indicators
KW - Genetic association
KW - Rs6525
KW - Val66Met
UR - http://www.scopus.com/inward/record.url?scp=84856319161&partnerID=8YFLogxK
U2 - 10.1111/j.1601-183X.2011.00738.x
DO - 10.1111/j.1601-183X.2011.00738.x
M3 - Article
C2 - 21980924
AN - SCOPUS:84856319161
VL - 11
SP - 127
EP - 136
JO - Genes, Brain and Behavior
JF - Genes, Brain and Behavior
SN - 1601-1848
IS - 2
ER -
ID: 87392574