TY - JOUR

T1 - Autoantibodies to vimentin different modifications in patients with tuberculosis and different granulomatous lung diseases

AU - Malkova, A.

AU - Starshinova, A.

AU - Lapin, S

AU - Surkova, E.

AU - Zinchenko, Ju.

AU - Basantsova, N.

AU - Gildburg, B.

AU - Yablonskiy, P.

PY - 2019/9/28

Y1 - 2019/9/28

N2 - Background: Tuberculosis is a granulomatous disease of infectious origin, etiology factor of it is M.Tuberculosis. M.Tuberculosis is known to induce autoimmune processes because of mimicry of bacterial proteins with autoantigens. Recently the attention of scientist was attracted to protein vimentin, that could be an autoantigen after micobaterial infection. The aim of the study is to measure the concentration of different autoantibodies to vimentin in patients with tuberculosis (TB) and different granulomatous lung diseases (GLD). Material and Methods: There were studied the serum samples of patients with TB (n=28), a group of GLD (n=30), that included 15 patients with granulomatous polyangiitis and 15 with various alveolites, and a control group (n=40) (healthy subjects). The level of antibodies to modified citrullinated vimentin (anti-MCV) and to cyclic citrullinated peptide (anti-CCP) were measured with ELISA. Statistical analysis was performed with the Microsoft Office software and GraphPad Prism 6. Suppo

AB - Background: Tuberculosis is a granulomatous disease of infectious origin, etiology factor of it is M.Tuberculosis. M.Tuberculosis is known to induce autoimmune processes because of mimicry of bacterial proteins with autoantigens. Recently the attention of scientist was attracted to protein vimentin, that could be an autoantigen after micobaterial infection. The aim of the study is to measure the concentration of different autoantibodies to vimentin in patients with tuberculosis (TB) and different granulomatous lung diseases (GLD). Material and Methods: There were studied the serum samples of patients with TB (n=28), a group of GLD (n=30), that included 15 patients with granulomatous polyangiitis and 15 with various alveolites, and a control group (n=40) (healthy subjects). The level of antibodies to modified citrullinated vimentin (anti-MCV) and to cyclic citrullinated peptide (anti-CCP) were measured with ELISA. Statistical analysis was performed with the Microsoft Office software and GraphPad Prism 6. Suppo

KW - Chronic diseases

KW - Biomarkers

KW - Immunology

U2 - 10.1183/13993003.congress-2019.PA3016

DO - 10.1183/13993003.congress-2019.PA3016

M3 - тезисы

VL - 54

SP - PA3016

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - S63

M1 - PA3016

Y2 - 28 September 2019 through 2 October 2019

ER -