Background: Tuberculosis is a granulomatous disease of infectious origin, etiology factor of it is M.Tuberculosis. M.Tuberculosis is known to induce autoimmune processes because of mimicry of bacterial proteins with autoantigens. Recently the attention of scientist was attracted to protein vimentin, that could be an autoantigen after micobaterial infection. The aim of the study is to measure the concentration of different autoantibodies to vimentin in patients with tuberculosis (TB) and different granulomatous lung diseases (GLD). Material and Methods: There were studied the serum samples of patients with TB (n=28), a group of GLD (n=30), that included 15 patients with granulomatous polyangiitis and 15 with various alveolites, and a control group (n=40) (healthy subjects). The level of antibodies to modified citrullinated vimentin (anti-MCV) and to cyclic citrullinated peptide (anti-CCP) were measured with ELISA. Statistical analysis was performed with the Microsoft Office software and GraphPad Prism 6. Suppo