Autoantibodies to 24 antigenes in various forms of tuberculosis and sarcoidosis on the background of vitamin d insufficiency.

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Autoantibodies to 24 antigenes in various forms of tuberculosis and sarcoidosis on the background of vitamin d insufficiency. / Беляева, Ирина Васильевна ; Чурилов, Леонид Павлович ; Михайлова, Лия Робертовна; Николаев, Алексей Владимирович; Старшинова, Анна Андреевна ; Яблонский, Петр Казимирович.

в: Russian Biomedical Research, Том 4, № 1, 2019, стр. 9-19.

Результаты исследований: Научные публикации в периодических изданиях › статья

BibTeX

@article{e7c17bafe1294b4b9d1a233b988ac07e,

title = "Autoantibodies to 24 antigenes in various forms of tuberculosis and sarcoidosis on the background of vitamin d insufficiency.",

abstract = "The vitamin D deficiency is associated with several autoimmune and chronic inflammatory diseasessuch as tuberculosis (TB) and sarcoidosis (Sr). We studied blood samples taken in March - April in Saint Petersburg area (59° north latitude) from patients with different forms of pulmonary tuberculosis, sarcoidosis, and from healthy donors, distinguishing between tuberculosis patients with short either long duration of disease. We measured the levels of calcifediol and calcitriol, prolactin in sera, cathelicidin in plasma, and the individual autoimmune profile of patients. The level of 25(OH) D was low even in healthy adult donors - 19.3±1.4 ng/ml; however in all patients it was significantly lower. Active metabolite 1.25(OH)2 D3 concentration in serum was increased only in the sarcoidosis patients. During infection the activated macrophages convert the main circulating form 25(OH) D into the active 1.25 (OH)2 D3 which induces the antibacterial peptide cathelicidin. We saw no expected increase of cathelicidin leve",

keywords = "autoantibodies, fibrous cavernous tuberculosis, infiltrative tuberculosis, sarcoidosis, vitamin D, аутоантитела, витамин Д, инфильтративный туберкулез, саркоидоз, фиброзно-кавернозный туберкулез, autoantibodies, fibrous cavernous tuberculosis, infiltrative tuberculosis, sarcoidosis, vitamin D, аутоантитела, витамин Д, инфильтративный туберкулез, саркоидоз, фиброзно-кавернозный туберкулез",

author = "Беляева, {Ирина Васильевна} and Чурилов, {Леонид Павлович} and Михайлова, {Лия Робертовна} and Николаев, {Алексей Владимирович} and Старшинова, {Анна Андреевна} and Яблонский, {Петр Казимирович}",

year = "2019",

language = "English",

volume = "4",

pages = "9--19",

journal = "РОССИЙСКИЕ БИОМЕДИЦИНСКИЕ ИССЛЕДОВАНИЯ",

issn = "2658-6584",

publisher = "Санкт-Петербургский государственный педиатрический медицинский университет",

number = "1",

}

RIS

TY - JOUR

T1 - Autoantibodies to 24 antigenes in various forms of tuberculosis and sarcoidosis on the background of vitamin d insufficiency.

AU - Беляева, Ирина Васильевна

AU - Чурилов, Леонид Павлович

AU - Михайлова, Лия Робертовна

AU - Николаев, Алексей Владимирович

AU - Старшинова, Анна Андреевна

AU - Яблонский, Петр Казимирович

PY - 2019

Y1 - 2019

N2 - The vitamin D deficiency is associated with several autoimmune and chronic inflammatory diseasessuch as tuberculosis (TB) and sarcoidosis (Sr). We studied blood samples taken in March - April in Saint Petersburg area (59° north latitude) from patients with different forms of pulmonary tuberculosis, sarcoidosis, and from healthy donors, distinguishing between tuberculosis patients with short either long duration of disease. We measured the levels of calcifediol and calcitriol, prolactin in sera, cathelicidin in plasma, and the individual autoimmune profile of patients. The level of 25(OH) D was low even in healthy adult donors - 19.3±1.4 ng/ml; however in all patients it was significantly lower. Active metabolite 1.25(OH)2 D3 concentration in serum was increased only in the sarcoidosis patients. During infection the activated macrophages convert the main circulating form 25(OH) D into the active 1.25 (OH)2 D3 which induces the antibacterial peptide cathelicidin. We saw no expected increase of cathelicidin leve

AB - The vitamin D deficiency is associated with several autoimmune and chronic inflammatory diseasessuch as tuberculosis (TB) and sarcoidosis (Sr). We studied blood samples taken in March - April in Saint Petersburg area (59° north latitude) from patients with different forms of pulmonary tuberculosis, sarcoidosis, and from healthy donors, distinguishing between tuberculosis patients with short either long duration of disease. We measured the levels of calcifediol and calcitriol, prolactin in sera, cathelicidin in plasma, and the individual autoimmune profile of patients. The level of 25(OH) D was low even in healthy adult donors - 19.3±1.4 ng/ml; however in all patients it was significantly lower. Active metabolite 1.25(OH)2 D3 concentration in serum was increased only in the sarcoidosis patients. During infection the activated macrophages convert the main circulating form 25(OH) D into the active 1.25 (OH)2 D3 which induces the antibacterial peptide cathelicidin. We saw no expected increase of cathelicidin leve

KW - autoantibodies

KW - fibrous cavernous tuberculosis

KW - infiltrative tuberculosis

KW - sarcoidosis

KW - vitamin D

KW - аутоантитела

KW - витамин Д

KW - инфильтративный туберкулез

KW - саркоидоз

KW - фиброзно-кавернозный туберкулез

KW - autoantibodies

KW - fibrous cavernous tuberculosis

KW - infiltrative tuberculosis

KW - sarcoidosis

KW - vitamin D

KW - аутоантитела

KW - витамин Д

KW - инфильтративный туберкулез

KW - саркоидоз

KW - фиброзно-кавернозный туберкулез

M3 - Article

VL - 4

SP - 9

EP - 19

JO - РОССИЙСКИЕ БИОМЕДИЦИНСКИЕ ИССЛЕДОВАНИЯ

JF - РОССИЙСКИЕ БИОМЕДИЦИНСКИЕ ИССЛЕДОВАНИЯ

SN - 2658-6584

IS - 1

ER -

ID: 78409113