Autoantibodies to 24 antigenes in various forms of tuberculosis and sarcoidosis on the background of vitamin d insufficiency. / Беляева, Ирина Васильевна; Чурилов, Леонид Павлович; Михайлова, Лия Робертовна; Николаев, Алексей Владимирович; Старшинова, Анна Андреевна; Яблонский, Петр Казимирович.
In: Russian Biomedical Research, Vol. 4, No. 1, 2019, p. 9-19.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Autoantibodies to 24 antigenes in various forms of tuberculosis and sarcoidosis on the background of vitamin d insufficiency.
AU - Беляева, Ирина Васильевна
AU - Чурилов, Леонид Павлович
AU - Михайлова, Лия Робертовна
AU - Николаев, Алексей Владимирович
AU - Старшинова, Анна Андреевна
AU - Яблонский, Петр Казимирович
PY - 2019
Y1 - 2019
N2 - The vitamin D deficiency is associated with several autoimmune and chronic inflammatory diseasessuch as tuberculosis (TB) and sarcoidosis (Sr). We studied blood samples taken in March - April in Saint Petersburg area (59° north latitude) from patients with different forms of pulmonary tuberculosis, sarcoidosis, and from healthy donors, distinguishing between tuberculosis patients with short either long duration of disease. We measured the levels of calcifediol and calcitriol, prolactin in sera, cathelicidin in plasma, and the individual autoimmune profile of patients. The level of 25(OH) D was low even in healthy adult donors - 19.3±1.4 ng/ml; however in all patients it was significantly lower. Active metabolite 1.25(OH)2 D3 concentration in serum was increased only in the sarcoidosis patients. During infection the activated macrophages convert the main circulating form 25(OH) D into the active 1.25 (OH)2 D3 which induces the antibacterial peptide cathelicidin. We saw no expected increase of cathelicidin leve
AB - The vitamin D deficiency is associated with several autoimmune and chronic inflammatory diseasessuch as tuberculosis (TB) and sarcoidosis (Sr). We studied blood samples taken in March - April in Saint Petersburg area (59° north latitude) from patients with different forms of pulmonary tuberculosis, sarcoidosis, and from healthy donors, distinguishing between tuberculosis patients with short either long duration of disease. We measured the levels of calcifediol and calcitriol, prolactin in sera, cathelicidin in plasma, and the individual autoimmune profile of patients. The level of 25(OH) D was low even in healthy adult donors - 19.3±1.4 ng/ml; however in all patients it was significantly lower. Active metabolite 1.25(OH)2 D3 concentration in serum was increased only in the sarcoidosis patients. During infection the activated macrophages convert the main circulating form 25(OH) D into the active 1.25 (OH)2 D3 which induces the antibacterial peptide cathelicidin. We saw no expected increase of cathelicidin leve
KW - autoantibodies
KW - fibrous cavernous tuberculosis
KW - infiltrative tuberculosis
KW - sarcoidosis
KW - vitamin D
KW - аутоантитела
KW - витамин Д
KW - инфильтративный туберкулез
KW - саркоидоз
KW - фиброзно-кавернозный туберкулез
KW - autoantibodies
KW - fibrous cavernous tuberculosis
KW - infiltrative tuberculosis
KW - sarcoidosis
KW - vitamin D
KW - аутоантитела
KW - витамин Д
KW - инфильтративный туберкулез
KW - саркоидоз
KW - фиброзно-кавернозный туберкулез
M3 - Article
VL - 4
SP - 9
EP - 19
JO - РОССИЙСКИЕ БИОМЕДИЦИНСКИЕ ИССЛЕДОВАНИЯ
JF - РОССИЙСКИЕ БИОМЕДИЦИНСКИЕ ИССЛЕДОВАНИЯ
SN - 2658-6584
IS - 1
ER -
ID: 78409113