TY - JOUR

T1 - Application of MALDI-MSI for detection of antimicrobial peptides in tissues of the marine invertebrate Arenicola marina

AU - Maltseva, A. L.

AU - Starunov, V. V.

AU - Zykin, P. A.

PY - 2016

Y1 - 2016

N2 - MALDI imaging mass-spectrometry (MALDI-MSI) is a highly informative approach combining morphology with molecular data. It is widely applied in neuroscience, plant science, cancer-biology, biomedicine, including clinical, and preclinical studies, but not for investigation of endogenous peptides/proteins or metabolites in marine invertebrates. We examined the informativeness of MALDI-MSI for analysis of distribution of antimicrobial peptides (arenicins) in the polychete Arenicola marina and concluded that it can be successfully used as a primary rough express screening method.

AB - MALDI imaging mass-spectrometry (MALDI-MSI) is a highly informative approach combining morphology with molecular data. It is widely applied in neuroscience, plant science, cancer-biology, biomedicine, including clinical, and preclinical studies, but not for investigation of endogenous peptides/proteins or metabolites in marine invertebrates. We examined the informativeness of MALDI-MSI for analysis of distribution of antimicrobial peptides (arenicins) in the polychete Arenicola marina and concluded that it can be successfully used as a primary rough express screening method.

KW - MALDI-MSI

KW - antimicrobial peptides

KW - polychete immunity

KW - Arenicola marina

M3 - Article

VL - 13

SP - 205

EP - 209

JO - Invertebrate Survival Journal

JF - Invertebrate Survival Journal

SN - 1824-307X

ER -