Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
An Eco-Friendly Stereoselective Synthesis of Novel Derivatives of Indeno[1,2-b]Pyrrole and Indeno[1,2-c]Pyridazine. / Gein, Vladimir L.; Nosova, Natalia V.; Yankin, Andrei N.; Bazhina, Alina Y.; Dmitriev, Maksim V.
в: Polycyclic Aromatic Compounds, 2019.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - An Eco-Friendly Stereoselective Synthesis of Novel Derivatives of Indeno[1,2-b]Pyrrole and Indeno[1,2-c]Pyridazine
AU - Gein, Vladimir L.
AU - Nosova, Natalia V.
AU - Yankin, Andrei N.
AU - Bazhina, Alina Y.
AU - Dmitriev, Maksim V.
PY - 2019
Y1 - 2019
N2 - A highly efficient and simple synthesis of a number of pharmaceutically interesting functionalized indenopirrole derivatives has been developed via the reaction of ninhydrin and acetoacetic acid amides in ethanol at the absence of catalyst at room temperature. In the case, then N,N-dialkylacetoacetamides were used as the methylene components, novel N,N-dialkyl-3-oxobutanamide derivatives were received. The novel indenopyridazine derivatives were first obtained via the reaction of indenopirroles with hydrazine. Environmental friendliness, mild reaction conditions, simple work-up avoiding chromatographic purification, and excellent yields are the important features of this protocol.
AB - A highly efficient and simple synthesis of a number of pharmaceutically interesting functionalized indenopirrole derivatives has been developed via the reaction of ninhydrin and acetoacetic acid amides in ethanol at the absence of catalyst at room temperature. In the case, then N,N-dialkylacetoacetamides were used as the methylene components, novel N,N-dialkyl-3-oxobutanamide derivatives were received. The novel indenopyridazine derivatives were first obtained via the reaction of indenopirroles with hydrazine. Environmental friendliness, mild reaction conditions, simple work-up avoiding chromatographic purification, and excellent yields are the important features of this protocol.
KW - Heterocycles
KW - indenopirroles
KW - indenopyridazines
KW - N,N-dialkyl-3-oxobutanamides
KW - ninhydrin
KW - ANALOGS
KW - QUATERNARY STEREOCENTERS
KW - CYCLIZATIONS
KW - 1,3-DIPOLAR CYCLOADDITION
KW - CONSTRUCTION
KW - GAMMA-LACTAMS
KW - SYSTEMS
KW - ACETYLCHOLINESTERASE INHIBITORS
KW - LIGAND
KW - TRANSFORMATIONS
UR - http://www.scopus.com/inward/record.url?scp=85064637989&partnerID=8YFLogxK
U2 - 10.1080/10406638.2019.1602061
DO - 10.1080/10406638.2019.1602061
M3 - Article
AN - SCOPUS:85064637989
JO - Polycyclic Aromatic Compounds
JF - Polycyclic Aromatic Compounds
SN - 1040-6638
ER -
ID: 41668165