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An Eco-Friendly Stereoselective Synthesis of Novel Derivatives of Indeno[1,2-b]Pyrrole and Indeno[1,2-c]Pyridazine. / Gein, Vladimir L.; Nosova, Natalia V.; Yankin, Andrei N.; Bazhina, Alina Y.; Dmitriev, Maksim V.

In: Polycyclic Aromatic Compounds, 2019.

Research output: Contribution to journal › Article › peer-review

Harvard

Gein, VL, Nosova, NV, Yankin, AN, Bazhina, AY & Dmitriev, MV 2019, 'An Eco-Friendly Stereoselective Synthesis of Novel Derivatives of Indeno[1,2-b]Pyrrole and Indeno[1,2-c]Pyridazine', Polycyclic Aromatic Compounds. https://doi.org/10.1080/10406638.2019.1602061

APA

Gein, V. L., Nosova, N. V., Yankin, A. N., Bazhina, A. Y., & Dmitriev, M. V. (2019). An Eco-Friendly Stereoselective Synthesis of Novel Derivatives of Indeno[1,2-b]Pyrrole and Indeno[1,2-c]Pyridazine. Polycyclic Aromatic Compounds. https://doi.org/10.1080/10406638.2019.1602061

Vancouver

Gein VL, Nosova NV, Yankin AN, Bazhina AY, Dmitriev MV. An Eco-Friendly Stereoselective Synthesis of Novel Derivatives of Indeno[1,2-b]Pyrrole and Indeno[1,2-c]Pyridazine. Polycyclic Aromatic Compounds. 2019. https://doi.org/10.1080/10406638.2019.1602061

Author

Gein, Vladimir L. ; Nosova, Natalia V. ; Yankin, Andrei N. ; Bazhina, Alina Y. ; Dmitriev, Maksim V. / An Eco-Friendly Stereoselective Synthesis of Novel Derivatives of Indeno[1,2-b]Pyrrole and Indeno[1,2-c]Pyridazine. In: Polycyclic Aromatic Compounds. 2019.

BibTeX

@article{8b7d57eba93b4ee49ed45350a47b6c5c,
title = "An Eco-Friendly Stereoselective Synthesis of Novel Derivatives of Indeno[1,2-b]Pyrrole and Indeno[1,2-c]Pyridazine",
abstract = "A highly efficient and simple synthesis of a number of pharmaceutically interesting functionalized indenopirrole derivatives has been developed via the reaction of ninhydrin and acetoacetic acid amides in ethanol at the absence of catalyst at room temperature. In the case, then N,N-dialkylacetoacetamides were used as the methylene components, novel N,N-dialkyl-3-oxobutanamide derivatives were received. The novel indenopyridazine derivatives were first obtained via the reaction of indenopirroles with hydrazine. Environmental friendliness, mild reaction conditions, simple work-up avoiding chromatographic purification, and excellent yields are the important features of this protocol.",
keywords = "Heterocycles, indenopirroles, indenopyridazines, N,N-dialkyl-3-oxobutanamides, ninhydrin, ANALOGS, QUATERNARY STEREOCENTERS, CYCLIZATIONS, 1,3-DIPOLAR CYCLOADDITION, CONSTRUCTION, GAMMA-LACTAMS, SYSTEMS, ACETYLCHOLINESTERASE INHIBITORS, LIGAND, TRANSFORMATIONS",
author = "Gein, {Vladimir L.} and Nosova, {Natalia V.} and Yankin, {Andrei N.} and Bazhina, {Alina Y.} and Dmitriev, {Maksim V.}",
year = "2019",
doi = "10.1080/10406638.2019.1602061",
language = "English",
journal = "Polycyclic Aromatic Compounds",
issn = "1040-6638",
publisher = "Taylor & Francis",

}

RIS

TY - JOUR

T1 - An Eco-Friendly Stereoselective Synthesis of Novel Derivatives of Indeno[1,2-b]Pyrrole and Indeno[1,2-c]Pyridazine

AU - Gein, Vladimir L.

AU - Nosova, Natalia V.

AU - Yankin, Andrei N.

AU - Bazhina, Alina Y.

AU - Dmitriev, Maksim V.

PY - 2019

Y1 - 2019

N2 - A highly efficient and simple synthesis of a number of pharmaceutically interesting functionalized indenopirrole derivatives has been developed via the reaction of ninhydrin and acetoacetic acid amides in ethanol at the absence of catalyst at room temperature. In the case, then N,N-dialkylacetoacetamides were used as the methylene components, novel N,N-dialkyl-3-oxobutanamide derivatives were received. The novel indenopyridazine derivatives were first obtained via the reaction of indenopirroles with hydrazine. Environmental friendliness, mild reaction conditions, simple work-up avoiding chromatographic purification, and excellent yields are the important features of this protocol.

AB - A highly efficient and simple synthesis of a number of pharmaceutically interesting functionalized indenopirrole derivatives has been developed via the reaction of ninhydrin and acetoacetic acid amides in ethanol at the absence of catalyst at room temperature. In the case, then N,N-dialkylacetoacetamides were used as the methylene components, novel N,N-dialkyl-3-oxobutanamide derivatives were received. The novel indenopyridazine derivatives were first obtained via the reaction of indenopirroles with hydrazine. Environmental friendliness, mild reaction conditions, simple work-up avoiding chromatographic purification, and excellent yields are the important features of this protocol.

KW - Heterocycles

KW - indenopirroles

KW - indenopyridazines

KW - N,N-dialkyl-3-oxobutanamides

KW - ninhydrin

KW - ANALOGS

KW - QUATERNARY STEREOCENTERS

KW - CYCLIZATIONS

KW - 1,3-DIPOLAR CYCLOADDITION

KW - CONSTRUCTION

KW - GAMMA-LACTAMS

KW - SYSTEMS

KW - ACETYLCHOLINESTERASE INHIBITORS

KW - LIGAND

KW - TRANSFORMATIONS

UR - http://www.scopus.com/inward/record.url?scp=85064637989&partnerID=8YFLogxK

U2 - 10.1080/10406638.2019.1602061

DO - 10.1080/10406638.2019.1602061

M3 - Article

AN - SCOPUS:85064637989

JO - Polycyclic Aromatic Compounds

JF - Polycyclic Aromatic Compounds

SN - 1040-6638

ER -

ID: 41668165