DOI

  • Dean Palejev
  • Wookyeon Hwang
  • Nicole Landi
  • Maria Eastman
  • Stephen J. Frost
  • Robert K. Fulbright
  • Judith R. Kidd
  • Kenneth K. Kidd
  • Graeme F. Mason
  • W. Einar Mencl
  • Carolyn Yrigollen
  • Kenneth R. Pugh
  • Elena L. Grigorenko

We provide an illustration of an application of the elastic net to a large number of common genetic variants in the context of the search for the genetic bases of an endophenotype conceivably related to individual differences in learning. GABA concentration in the occipital cortex, a critical area for reading, was obtained in a group (n = 76) of children aged 6-10 years. Two extreme groups, high and low, were selected for genotyping with the 650Y Illumina array chip (Ilmn650Y). An elastic net approach was applied to the resulting SNP dataset; 100 SNPs were identified for each chromosome as "interesting" based on having the highest absolute value coefficients. The analyses highlighted chromosomes 15 and 20, which contained 55 candidate genes. The STRING partner analyses of the associated proteins pointed to a number of related genes, most notably, GABA and NTRK receptors.

Язык оригиналаанглийский
Страницы (с-по)120-124
Число страниц5
ЖурналBehavior Genetics
Том41
Номер выпуска1
DOI
СостояниеОпубликовано - янв 2011

    Предметные области Scopus

  • Экология, эволюция поведение и систематика
  • Генетика
  • Генетика (клиническая)

ID: 87395456