TY - JOUR

T1 - Amitriptyline attenuates Ca2+ responses induced by glutoxim and molixan in macrophages

AU - Z.I.Krutetskaya, null

AU - L.S. Milenina, null

AU - A.A. Naumova, null

AU - S.N. Butov, null

AU - V.G. Antonov, null

AU - A.D. Nozdrachev, null

N1 - Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A. et al. Amitriptyline Attenuates Ca2+ Responses Induced by Glutoxim and Molixan in Macrophages. Dokl Biochem Biophys 481, 222–224 (2018). https://doi.org/10.1134/S1607672918040117

PY - 2018

Y1 - 2018

N2 - Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca 2+-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca 2+ concentration increase in macrophages.

AB - Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca 2+-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca 2+ concentration increase in macrophages.

KW - ENDOTHELIAL-CELLS

KW - ENTRY

KW - PHARMACOLOGY

KW - RECEPTORS

UR - http://www.scopus.com/inward/record.url?scp=85052742135&partnerID=8YFLogxK

U2 - 10.1134/S1607672918040117

DO - 10.1134/S1607672918040117

M3 - Article

VL - 481

SP - 222

EP - 224

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

ER -