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Amitriptyline attenuates Ca2+ responses induced by glutoxim and molixan in macrophages. / Z.I.Krutetskaya, ; L.S. Milenina, ; A.A. Naumova, ; S.N. Butov; V.G. Antonov, ; A.D. Nozdrachev.

In: Doklady Biochemistry and Biophysics, Vol. 481, No. 1, 2018, p. 222-224.

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@article{b8bcc9ea12874e24a883c5f07f5784eb,
title = "Amitriptyline attenuates Ca2+ responses induced by glutoxim and molixan in macrophages",
abstract = "Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca 2+-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca 2+ concentration increase in macrophages. ",
keywords = "ENDOTHELIAL-CELLS, ENTRY, PHARMACOLOGY, RECEPTORS",
author = "Z.I.Krutetskaya and {L.S. Milenina} and {A.A. Naumova} and {S.N. Butov} and {V.G. Antonov} and {A.D. Nozdrachev}",
note = "Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A. et al. Amitriptyline Attenuates Ca2+ Responses Induced by Glutoxim and Molixan in Macrophages. Dokl Biochem Biophys 481, 222–224 (2018). https://doi.org/10.1134/S1607672918040117",
year = "2018",
doi = "10.1134/S1607672918040117",
language = "English",
volume = "481",
pages = "222--224",
journal = "Doklady Biochemistry and Biophysics",
issn = "1607-6729",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "1",

}

RIS

TY - JOUR

T1 - Amitriptyline attenuates Ca2+ responses induced by glutoxim and molixan in macrophages

AU - Z.I.Krutetskaya, null

AU - L.S. Milenina, null

AU - A.A. Naumova, null

AU - S.N. Butov, null

AU - V.G. Antonov, null

AU - A.D. Nozdrachev, null

N1 - Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A. et al. Amitriptyline Attenuates Ca2+ Responses Induced by Glutoxim and Molixan in Macrophages. Dokl Biochem Biophys 481, 222–224 (2018). https://doi.org/10.1134/S1607672918040117

PY - 2018

Y1 - 2018

N2 - Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca 2+-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca 2+ concentration increase in macrophages.

AB - Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca 2+-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca 2+ concentration increase in macrophages.

KW - ENDOTHELIAL-CELLS

KW - ENTRY

KW - PHARMACOLOGY

KW - RECEPTORS

UR - http://www.scopus.com/inward/record.url?scp=85052742135&partnerID=8YFLogxK

U2 - 10.1134/S1607672918040117

DO - 10.1134/S1607672918040117

M3 - Article

VL - 481

SP - 222

EP - 224

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

ER -

ID: 35252074