Research output: Contribution to journal › Article › peer-review
Amitriptyline attenuates Ca2+ responses induced by glutoxim and molixan in macrophages. / Z.I.Krutetskaya, ; L.S. Milenina, ; A.A. Naumova, ; S.N. Butov; V.G. Antonov, ; A.D. Nozdrachev.
In: Doklady Biochemistry and Biophysics, Vol. 481, No. 1, 2018, p. 222-224.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Amitriptyline attenuates Ca2+ responses induced by glutoxim and molixan in macrophages
AU - Z.I.Krutetskaya, null
AU - L.S. Milenina, null
AU - A.A. Naumova, null
AU - S.N. Butov, null
AU - V.G. Antonov, null
AU - A.D. Nozdrachev, null
N1 - Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A. et al. Amitriptyline Attenuates Ca2+ Responses Induced by Glutoxim and Molixan in Macrophages. Dokl Biochem Biophys 481, 222–224 (2018). https://doi.org/10.1134/S1607672918040117
PY - 2018
Y1 - 2018
N2 - Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca 2+-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca 2+ concentration increase in macrophages.
AB - Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca 2+-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca 2+ concentration increase in macrophages.
KW - ENDOTHELIAL-CELLS
KW - ENTRY
KW - PHARMACOLOGY
KW - RECEPTORS
UR - http://www.scopus.com/inward/record.url?scp=85052742135&partnerID=8YFLogxK
U2 - 10.1134/S1607672918040117
DO - 10.1134/S1607672918040117
M3 - Article
VL - 481
SP - 222
EP - 224
JO - Doklady Biochemistry and Biophysics
JF - Doklady Biochemistry and Biophysics
SN - 1607-6729
IS - 1
ER -
ID: 35252074