Результаты исследований: Научные публикации в периодических изданиях › статья
Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. / Pei, Y.; Lee, J.; Leo, D.; Gainetdinov, R.R.; Hoener, M.C.; Canales, J.J.
в: Neuropsychopharmacology, Том 39, № 10, 2014, стр. 2299-2308.Результаты исследований: Научные публикации в периодических изданиях › статья
}
TY - JOUR
T1 - Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking
AU - Pei, Y.
AU - Lee, J.
AU - Leo, D.
AU - Gainetdinov, R.R.
AU - Hoener, M.C.
AU - Canales, J.J.
PY - 2014
Y1 - 2014
N2 - The trace amine-associated receptor 1 (TAR1) has emerged as a promising target for medication development in addiction because of its ability to regulate dopamine (DA) transmission. We tested in rats the efficacy of RO5203648 and RO5256390, partial and full TAAR1 agonists, respectively, in models of cocaine relapse. Using a model of context-induced relapse, both RO5203648 and RO5256390 dose-dependently suppressed cocaine seeking after a 2-week period of withdrawal from chronic cocaine self-administration. In a model of extinction-reinstatement, RO5203648 completely inhibited cocaine-primed reinstatement of cocaine seeking. At doses that effectively suppressed cocaine seeking neither RO5203648 nor RO5256390 altered responding maintained by a natural reward. Moreover, fast scan cyclic voltammetry data showed that RO5203648 prevented cocaine-induced DA overflow in the nucleus accumbens without altering DA half-life, suggesting that the partial TAAR1 agonist attenuated cocaine-stimulated DA overflow by mechani
AB - The trace amine-associated receptor 1 (TAR1) has emerged as a promising target for medication development in addiction because of its ability to regulate dopamine (DA) transmission. We tested in rats the efficacy of RO5203648 and RO5256390, partial and full TAAR1 agonists, respectively, in models of cocaine relapse. Using a model of context-induced relapse, both RO5203648 and RO5256390 dose-dependently suppressed cocaine seeking after a 2-week period of withdrawal from chronic cocaine self-administration. In a model of extinction-reinstatement, RO5203648 completely inhibited cocaine-primed reinstatement of cocaine seeking. At doses that effectively suppressed cocaine seeking neither RO5203648 nor RO5256390 altered responding maintained by a natural reward. Moreover, fast scan cyclic voltammetry data showed that RO5203648 prevented cocaine-induced DA overflow in the nucleus accumbens without altering DA half-life, suggesting that the partial TAAR1 agonist attenuated cocaine-stimulated DA overflow by mechani
U2 - 10.1038/npp.2014.88
DO - 10.1038/npp.2014.88
M3 - Article
VL - 39
SP - 2299
EP - 2308
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
SN - 0893-133X
IS - 10
ER -
ID: 7018478