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Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. / Pei, Y.; Lee, J.; Leo, D.; Gainetdinov, R.R.; Hoener, M.C.; Canales, J.J.

In: Neuropsychopharmacology, Vol. 39, No. 10, 2014, p. 2299-2308.

Research output: Contribution to journal › Article

Harvard

Pei, Y, Lee, J, Leo, D, Gainetdinov, RR, Hoener, MC & Canales, JJ 2014, 'Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking', Neuropsychopharmacology, vol. 39, no. 10, pp. 2299-2308. https://doi.org/10.1038/npp.2014.88

APA

Pei, Y., Lee, J., Leo, D., Gainetdinov, R. R., Hoener, M. C., & Canales, J. J. (2014). Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. Neuropsychopharmacology, 39(10), 2299-2308. https://doi.org/10.1038/npp.2014.88

Vancouver

Pei Y, Lee J, Leo D, Gainetdinov RR, Hoener MC, Canales JJ. Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. Neuropsychopharmacology. 2014;39(10):2299-2308. https://doi.org/10.1038/npp.2014.88

Author

Pei, Y. ; Lee, J. ; Leo, D. ; Gainetdinov, R.R. ; Hoener, M.C. ; Canales, J.J. / Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. In: Neuropsychopharmacology. 2014 ; Vol. 39, No. 10. pp. 2299-2308.

BibTeX

@article{8c32d5a4bcfb4adf978bd275891f9bb3,
title = "Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking",
abstract = "The trace amine-associated receptor 1 (TAR1) has emerged as a promising target for medication development in addiction because of its ability to regulate dopamine (DA) transmission. We tested in rats the efficacy of RO5203648 and RO5256390, partial and full TAAR1 agonists, respectively, in models of cocaine relapse. Using a model of context-induced relapse, both RO5203648 and RO5256390 dose-dependently suppressed cocaine seeking after a 2-week period of withdrawal from chronic cocaine self-administration. In a model of extinction-reinstatement, RO5203648 completely inhibited cocaine-primed reinstatement of cocaine seeking. At doses that effectively suppressed cocaine seeking neither RO5203648 nor RO5256390 altered responding maintained by a natural reward. Moreover, fast scan cyclic voltammetry data showed that RO5203648 prevented cocaine-induced DA overflow in the nucleus accumbens without altering DA half-life, suggesting that the partial TAAR1 agonist attenuated cocaine-stimulated DA overflow by mechani",
author = "Y. Pei and J. Lee and D. Leo and R.R. Gainetdinov and M.C. Hoener and J.J. Canales",
year = "2014",
doi = "10.1038/npp.2014.88",
language = "English",
volume = "39",
pages = "2299--2308",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "10",

}

RIS

TY - JOUR

T1 - Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking

AU - Pei, Y.

AU - Lee, J.

AU - Leo, D.

AU - Gainetdinov, R.R.

AU - Hoener, M.C.

AU - Canales, J.J.

PY - 2014

Y1 - 2014

N2 - The trace amine-associated receptor 1 (TAR1) has emerged as a promising target for medication development in addiction because of its ability to regulate dopamine (DA) transmission. We tested in rats the efficacy of RO5203648 and RO5256390, partial and full TAAR1 agonists, respectively, in models of cocaine relapse. Using a model of context-induced relapse, both RO5203648 and RO5256390 dose-dependently suppressed cocaine seeking after a 2-week period of withdrawal from chronic cocaine self-administration. In a model of extinction-reinstatement, RO5203648 completely inhibited cocaine-primed reinstatement of cocaine seeking. At doses that effectively suppressed cocaine seeking neither RO5203648 nor RO5256390 altered responding maintained by a natural reward. Moreover, fast scan cyclic voltammetry data showed that RO5203648 prevented cocaine-induced DA overflow in the nucleus accumbens without altering DA half-life, suggesting that the partial TAAR1 agonist attenuated cocaine-stimulated DA overflow by mechani

AB - The trace amine-associated receptor 1 (TAR1) has emerged as a promising target for medication development in addiction because of its ability to regulate dopamine (DA) transmission. We tested in rats the efficacy of RO5203648 and RO5256390, partial and full TAAR1 agonists, respectively, in models of cocaine relapse. Using a model of context-induced relapse, both RO5203648 and RO5256390 dose-dependently suppressed cocaine seeking after a 2-week period of withdrawal from chronic cocaine self-administration. In a model of extinction-reinstatement, RO5203648 completely inhibited cocaine-primed reinstatement of cocaine seeking. At doses that effectively suppressed cocaine seeking neither RO5203648 nor RO5256390 altered responding maintained by a natural reward. Moreover, fast scan cyclic voltammetry data showed that RO5203648 prevented cocaine-induced DA overflow in the nucleus accumbens without altering DA half-life, suggesting that the partial TAAR1 agonist attenuated cocaine-stimulated DA overflow by mechani

U2 - 10.1038/npp.2014.88

DO - 10.1038/npp.2014.88

M3 - Article

VL - 39

SP - 2299

EP - 2308

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 10

ER -

ID: 7018478