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Activation of interleukin-2 gene transcription by nuclear factors from the spleen and brain of immunized rats. / Grishina, T. V.; Golovko, O. I.; Gushchin, G. V.; Myul'berg, A. A.

в: Bulletin of Experimental Biology and Medicine, Том 117, № 5, 01.05.1994, стр. 522-525.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Grishina, TV, Golovko, OI, Gushchin, GV & Myul'berg, AA 1994, 'Activation of interleukin-2 gene transcription by nuclear factors from the spleen and brain of immunized rats', Bulletin of Experimental Biology and Medicine, Том. 117, № 5, стр. 522-525. https://doi.org/10.1007/BF02444307

APA

Grishina, T. V., Golovko, O. I., Gushchin, G. V., & Myul'berg, A. A. (1994). Activation of interleukin-2 gene transcription by nuclear factors from the spleen and brain of immunized rats. Bulletin of Experimental Biology and Medicine, 117(5), 522-525. https://doi.org/10.1007/BF02444307

Vancouver

Grishina TV, Golovko OI, Gushchin GV, Myul'berg AA. Activation of interleukin-2 gene transcription by nuclear factors from the spleen and brain of immunized rats. Bulletin of Experimental Biology and Medicine. 1994 Май 1;117(5):522-525. https://doi.org/10.1007/BF02444307

Author

Grishina, T. V. ; Golovko, O. I. ; Gushchin, G. V. ; Myul'berg, A. A. / Activation of interleukin-2 gene transcription by nuclear factors from the spleen and brain of immunized rats. в: Bulletin of Experimental Biology and Medicine. 1994 ; Том 117, № 5. стр. 522-525.

BibTeX

@article{3634e6b6d75f4f3489edcf7674b2dc7e,
title = "Activation of interleukin-2 gene transcription by nuclear factors from the spleen and brain of immunized rats",
abstract = "The nuclear protein factors which stimulate synthesis of mRNA of interleukin-2 (IL-2) in the system of surviving murine T lymphocytes are isolated from cells of the spleen and brain of immunized rats. The active fractions of spleen and brain (13-19 and 25 kD, respectively), which interact with the promoter-enhancer sequences of the IL-2 gene localized in the region from +39 to -141 base pairs, are isolated by the method of high performance liquid chromatography from the total nuclear extract. The induction of luciferase synthesis is shown for protein factor-treated Jurkat cells transformed with p-IL-2LUC recombinant plasmid.",
keywords = "interleukin-2 gene, protein factors, regulation",
author = "Grishina, {T. V.} and Golovko, {O. I.} and Gushchin, {G. V.} and Myul'berg, {A. A.}",
year = "1994",
month = may,
day = "1",
doi = "10.1007/BF02444307",
language = "English",
volume = "117",
pages = "522--525",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer Nature",
number = "5",

}

RIS

TY - JOUR

T1 - Activation of interleukin-2 gene transcription by nuclear factors from the spleen and brain of immunized rats

AU - Grishina, T. V.

AU - Golovko, O. I.

AU - Gushchin, G. V.

AU - Myul'berg, A. A.

PY - 1994/5/1

Y1 - 1994/5/1

N2 - The nuclear protein factors which stimulate synthesis of mRNA of interleukin-2 (IL-2) in the system of surviving murine T lymphocytes are isolated from cells of the spleen and brain of immunized rats. The active fractions of spleen and brain (13-19 and 25 kD, respectively), which interact with the promoter-enhancer sequences of the IL-2 gene localized in the region from +39 to -141 base pairs, are isolated by the method of high performance liquid chromatography from the total nuclear extract. The induction of luciferase synthesis is shown for protein factor-treated Jurkat cells transformed with p-IL-2LUC recombinant plasmid.

AB - The nuclear protein factors which stimulate synthesis of mRNA of interleukin-2 (IL-2) in the system of surviving murine T lymphocytes are isolated from cells of the spleen and brain of immunized rats. The active fractions of spleen and brain (13-19 and 25 kD, respectively), which interact with the promoter-enhancer sequences of the IL-2 gene localized in the region from +39 to -141 base pairs, are isolated by the method of high performance liquid chromatography from the total nuclear extract. The induction of luciferase synthesis is shown for protein factor-treated Jurkat cells transformed with p-IL-2LUC recombinant plasmid.

KW - interleukin-2 gene

KW - protein factors

KW - regulation

UR - http://www.scopus.com/inward/record.url?scp=51649133297&partnerID=8YFLogxK

U2 - 10.1007/BF02444307

DO - 10.1007/BF02444307

M3 - Article

AN - SCOPUS:51649133297

VL - 117

SP - 522

EP - 525

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 5

ER -

ID: 35960196