Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
The nuclear protein factors which stimulate synthesis of mRNA of interleukin-2 (IL-2) in the system of surviving murine T lymphocytes are isolated from cells of the spleen and brain of immunized rats. The active fractions of spleen and brain (13-19 and 25 kD, respectively), which interact with the promoter-enhancer sequences of the IL-2 gene localized in the region from +39 to -141 base pairs, are isolated by the method of high performance liquid chromatography from the total nuclear extract. The induction of luciferase synthesis is shown for protein factor-treated Jurkat cells transformed with p-IL-2LUC recombinant plasmid.
Язык оригинала | английский |
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Страницы (с-по) | 522-525 |
Число страниц | 4 |
Журнал | Bulletin of Experimental Biology and Medicine |
Том | 117 |
Номер выпуска | 5 |
DOI | |
Состояние | Опубликовано - 1 мая 1994 |
ID: 35960196