TY - JOUR

T1 - A Study of the Association between Breastfeeding and DNA Methylation in Peripheral Blood Cells of Infants

AU - Naumova, O. Yu

AU - Odintsova, V. V.

AU - Arincina, I. A.

AU - Rychkov, S. Yu

AU - Muhamedrahimov, R. J.

AU - Shneider, Yu V.

AU - Grosheva, A. N.

AU - Zhukova, O. V.

AU - Grigorenko, E. L.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - This article reports on new data on the association of breastfeeding with DNA methylation in the peripheral blood cells of 37 children aged from 9 months to four years. Whole-genome DNA methylation profiling was performed using the Illumina Methylation EPIC array. The Epigenome-Wide Association Study (EWAS) revealed an association between the duration of breastfeeding and the methylation level of 4276 CpG sites related to 2635 genes. According to the functional annotation, these genes were predominantly involved in the control of cell signaling systems, the development of anatomical structures and cells, and, above all, were related to the development and function of the immune system and the CNS. The results of the study allowed assuming a special role of the oxytocin signaling pathway, as a potential trigger of coordinated epigenetic changes in the genes involved in the CNS function in response to breastfeeding.

AB - This article reports on new data on the association of breastfeeding with DNA methylation in the peripheral blood cells of 37 children aged from 9 months to four years. Whole-genome DNA methylation profiling was performed using the Illumina Methylation EPIC array. The Epigenome-Wide Association Study (EWAS) revealed an association between the duration of breastfeeding and the methylation level of 4276 CpG sites related to 2635 genes. According to the functional annotation, these genes were predominantly involved in the control of cell signaling systems, the development of anatomical structures and cells, and, above all, were related to the development and function of the immune system and the CNS. The results of the study allowed assuming a special role of the oxytocin signaling pathway, as a potential trigger of coordinated epigenetic changes in the genes involved in the CNS function in response to breastfeeding.

KW - breastfeeding

KW - genome-wide DNA methylation

KW - Illumina Methylation EPIC microarray

KW - peripheral blood lymphocytes

KW - GENE

KW - CHILDREN

UR - http://www.scopus.com/inward/record.url?scp=85068548386&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/study-association-between-breastfeeding-dna-methylation-peripheral-blood-cells-infants

U2 - 10.1134/S1022795419060103

DO - 10.1134/S1022795419060103

M3 - статья

AN - SCOPUS:85068548386

VL - 55

SP - 749

EP - 755

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 6

ER -