Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
A cytostatic drug from the class of triazine derivatives : Its properties in aqueous solutions, cytotoxicity, and therapeutic activity. / Mikolaichuk, Olga V.; Popova, Elena A.; Protas, Alexandra V.; Rakipov, Ilnaz T.; Nerukh, Dmitry A.; Petrov, Andrey V.; Charykov, Nikolay A.; Ageev, Sergei V.; Tochilnikov, Grigorii V.; Zmitrichenko, Iulia G.; Stukov, Aleksandr N.; Semenov, Konstantin N.; Sharoyko, Vladimir V.
в: Journal of Molecular Liquids, Том 356, 119043, 15.06.2022.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - A cytostatic drug from the class of triazine derivatives
T2 - Its properties in aqueous solutions, cytotoxicity, and therapeutic activity
AU - Mikolaichuk, Olga V.
AU - Popova, Elena A.
AU - Protas, Alexandra V.
AU - Rakipov, Ilnaz T.
AU - Nerukh, Dmitry A.
AU - Petrov, Andrey V.
AU - Charykov, Nikolay A.
AU - Ageev, Sergei V.
AU - Tochilnikov, Grigorii V.
AU - Zmitrichenko, Iulia G.
AU - Stukov, Aleksandr N.
AU - Semenov, Konstantin N.
AU - Sharoyko, Vladimir V.
N1 - Publisher Copyright: © 2022 Elsevier B.V.
PY - 2022/6/15
Y1 - 2022/6/15
N2 - We present a comprehensive study of a water-soluble substance from the class of triazine derivatives alkylating agents. The performed physicochemical investigations of this cytostatic drug's aqueous solutions include the measurements of density, viscosity, speed of sound, refraction index, stability, solubility, distribution between water and octan-1-ol, as well as electronic structure calculations and molecular dynamics modelling. Biologically, the substance was investigated for its cytotoxicity as well as in vitro (on Capan-2 and SK-MEL-1 cell lines) and in vivo (transplantable Ehrlich ascites carcinoma model) therapeutic activity.
AB - We present a comprehensive study of a water-soluble substance from the class of triazine derivatives alkylating agents. The performed physicochemical investigations of this cytostatic drug's aqueous solutions include the measurements of density, viscosity, speed of sound, refraction index, stability, solubility, distribution between water and octan-1-ol, as well as electronic structure calculations and molecular dynamics modelling. Biologically, the substance was investigated for its cytotoxicity as well as in vitro (on Capan-2 and SK-MEL-1 cell lines) and in vivo (transplantable Ehrlich ascites carcinoma model) therapeutic activity.
KW - Cytostatic Agent
KW - Cytotoxicity
KW - Ehrlich ascites carcinoma
KW - Electronic structure
KW - Molecular Dynamics
KW - Solutions
UR - http://www.scopus.com/inward/record.url?scp=85127512751&partnerID=8YFLogxK
U2 - 10.1016/j.molliq.2022.119043
DO - 10.1016/j.molliq.2022.119043
M3 - Article
AN - SCOPUS:85127512751
VL - 356
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
SN - 0167-7322
M1 - 119043
ER -
ID: 96220319