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A cytostatic drug from the class of triazine derivatives : Its properties in aqueous solutions, cytotoxicity, and therapeutic activity. / Mikolaichuk, Olga V.; Popova, Elena A.; Protas, Alexandra V.; Rakipov, Ilnaz T.; Nerukh, Dmitry A.; Petrov, Andrey V.; Charykov, Nikolay A.; Ageev, Sergei V.; Tochilnikov, Grigorii V.; Zmitrichenko, Iulia G.; Stukov, Aleksandr N.; Semenov, Konstantin N.; Sharoyko, Vladimir V.

In: Journal of Molecular Liquids, Vol. 356, 119043, 15.06.2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Mikolaichuk, OV, Popova, EA, Protas, AV, Rakipov, IT, Nerukh, DA, Petrov, AV, Charykov, NA, Ageev, SV, Tochilnikov, GV, Zmitrichenko, IG, Stukov, AN, Semenov, KN & Sharoyko, VV 2022, 'A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity', Journal of Molecular Liquids, vol. 356, 119043. https://doi.org/10.1016/j.molliq.2022.119043

APA

Mikolaichuk, O. V., Popova, E. A., Protas, A. V., Rakipov, I. T., Nerukh, D. A., Petrov, A. V., Charykov, N. A., Ageev, S. V., Tochilnikov, G. V., Zmitrichenko, I. G., Stukov, A. N., Semenov, K. N., & Sharoyko, V. V. (2022). A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity. Journal of Molecular Liquids, 356, [119043]. https://doi.org/10.1016/j.molliq.2022.119043

Vancouver

Mikolaichuk OV, Popova EA, Protas AV, Rakipov IT, Nerukh DA, Petrov AV et al. A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity. Journal of Molecular Liquids. 2022 Jun 15;356. 119043. https://doi.org/10.1016/j.molliq.2022.119043

Author

Mikolaichuk, Olga V. ; Popova, Elena A. ; Protas, Alexandra V. ; Rakipov, Ilnaz T. ; Nerukh, Dmitry A. ; Petrov, Andrey V. ; Charykov, Nikolay A. ; Ageev, Sergei V. ; Tochilnikov, Grigorii V. ; Zmitrichenko, Iulia G. ; Stukov, Aleksandr N. ; Semenov, Konstantin N. ; Sharoyko, Vladimir V. / A cytostatic drug from the class of triazine derivatives : Its properties in aqueous solutions, cytotoxicity, and therapeutic activity. In: Journal of Molecular Liquids. 2022 ; Vol. 356.

BibTeX

@article{cafdcf480e6d4e8499337492289301eb,
title = "A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity",
abstract = "We present a comprehensive study of a water-soluble substance from the class of triazine derivatives alkylating agents. The performed physicochemical investigations of this cytostatic drug's aqueous solutions include the measurements of density, viscosity, speed of sound, refraction index, stability, solubility, distribution between water and octan-1-ol, as well as electronic structure calculations and molecular dynamics modelling. Biologically, the substance was investigated for its cytotoxicity as well as in vitro (on Capan-2 and SK-MEL-1 cell lines) and in vivo (transplantable Ehrlich ascites carcinoma model) therapeutic activity.",
keywords = "Cytostatic Agent, Cytotoxicity, Ehrlich ascites carcinoma, Electronic structure, Molecular Dynamics, Solutions",
author = "Mikolaichuk, {Olga V.} and Popova, {Elena A.} and Protas, {Alexandra V.} and Rakipov, {Ilnaz T.} and Nerukh, {Dmitry A.} and Petrov, {Andrey V.} and Charykov, {Nikolay A.} and Ageev, {Sergei V.} and Tochilnikov, {Grigorii V.} and Zmitrichenko, {Iulia G.} and Stukov, {Aleksandr N.} and Semenov, {Konstantin N.} and Sharoyko, {Vladimir V.}",
note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",
year = "2022",
month = jun,
day = "15",
doi = "10.1016/j.molliq.2022.119043",
language = "English",
volume = "356",
journal = "Journal of Molecular Liquids",
issn = "0167-7322",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - A cytostatic drug from the class of triazine derivatives

T2 - Its properties in aqueous solutions, cytotoxicity, and therapeutic activity

AU - Mikolaichuk, Olga V.

AU - Popova, Elena A.

AU - Protas, Alexandra V.

AU - Rakipov, Ilnaz T.

AU - Nerukh, Dmitry A.

AU - Petrov, Andrey V.

AU - Charykov, Nikolay A.

AU - Ageev, Sergei V.

AU - Tochilnikov, Grigorii V.

AU - Zmitrichenko, Iulia G.

AU - Stukov, Aleksandr N.

AU - Semenov, Konstantin N.

AU - Sharoyko, Vladimir V.

N1 - Publisher Copyright: © 2022 Elsevier B.V.

PY - 2022/6/15

Y1 - 2022/6/15

N2 - We present a comprehensive study of a water-soluble substance from the class of triazine derivatives alkylating agents. The performed physicochemical investigations of this cytostatic drug's aqueous solutions include the measurements of density, viscosity, speed of sound, refraction index, stability, solubility, distribution between water and octan-1-ol, as well as electronic structure calculations and molecular dynamics modelling. Biologically, the substance was investigated for its cytotoxicity as well as in vitro (on Capan-2 and SK-MEL-1 cell lines) and in vivo (transplantable Ehrlich ascites carcinoma model) therapeutic activity.

AB - We present a comprehensive study of a water-soluble substance from the class of triazine derivatives alkylating agents. The performed physicochemical investigations of this cytostatic drug's aqueous solutions include the measurements of density, viscosity, speed of sound, refraction index, stability, solubility, distribution between water and octan-1-ol, as well as electronic structure calculations and molecular dynamics modelling. Biologically, the substance was investigated for its cytotoxicity as well as in vitro (on Capan-2 and SK-MEL-1 cell lines) and in vivo (transplantable Ehrlich ascites carcinoma model) therapeutic activity.

KW - Cytostatic Agent

KW - Cytotoxicity

KW - Ehrlich ascites carcinoma

KW - Electronic structure

KW - Molecular Dynamics

KW - Solutions

UR - http://www.scopus.com/inward/record.url?scp=85127512751&partnerID=8YFLogxK

U2 - 10.1016/j.molliq.2022.119043

DO - 10.1016/j.molliq.2022.119043

M3 - Article

AN - SCOPUS:85127512751

VL - 356

JO - Journal of Molecular Liquids

JF - Journal of Molecular Liquids

SN - 0167-7322

M1 - 119043

ER -

ID: 96220319