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1,3,5-Triazinanes as Formaldimine Surrogates in the Ugi Reaction. / Golubev, Pavel; Guranova, Natalia; Krasavin, Mikhail.
в: European Journal of Organic Chemistry, Том 2020, № 29, 09.08.2020, стр. 4517-4520.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - 1,3,5-Triazinanes as Formaldimine Surrogates in the Ugi Reaction
AU - Golubev, Pavel
AU - Guranova, Natalia
AU - Krasavin, Mikhail
PY - 2020/8/9
Y1 - 2020/8/9
N2 - In the present study, a new synthetic strategy towards N-acylated glycinamides was developed by the use of 1,3,5-triazinanes as formaldimine surrogates in the Ugi reaction. The targeted products were obtained in a combinatorial, diversity-oriented fashion in good yields. Further modifications allowed us to adapt this procedure for the one-pot two-step syntheses of a local anesthetic druglidocaine and several unsymmetrically substituted diketopiperazines.
AB - In the present study, a new synthetic strategy towards N-acylated glycinamides was developed by the use of 1,3,5-triazinanes as formaldimine surrogates in the Ugi reaction. The targeted products were obtained in a combinatorial, diversity-oriented fashion in good yields. Further modifications allowed us to adapt this procedure for the one-pot two-step syntheses of a local anesthetic druglidocaine and several unsymmetrically substituted diketopiperazines.
KW - 1,3,5-Triazinanes
KW - Molecular diversity
KW - Multicomponent reactions
KW - Synthetic methods
KW - Ugi reaction
UR - http://www.scopus.com/inward/record.url?scp=85088103523&partnerID=8YFLogxK
U2 - 10.1002/ejoc.202000569
DO - 10.1002/ejoc.202000569
M3 - Article
AN - SCOPUS:85088103523
VL - 2020
SP - 4517
EP - 4520
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
SN - 1434-193X
IS - 29
ER -
ID: 61393926