клонидина и дексмедетомидина для профилактики нейрокогнитивных нарушений в ближайшем послеоперационном периоде после аортокоронарного шунтирования

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клонидина и дексмедетомидина для профилактики нейрокогнитивных нарушений в ближайшем послеоперационном периоде после аортокоронарного шунтирования. / Balandina, E. V.; Volchkov, V. A.; Boyarkin, A. A.; Nefedov, A. V.; Kovalev, S. V.

в: Russian Journal of Anesthesiology and Reanimatology, Том 2020, № 4, 2020, стр. 42-47.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{517a9cac276c46d5bd67d5c2bd2ef7ad,

title = "клонидина и дексмедетомидина для профилактики нейрокогнитивных нарушений в ближайшем послеоперационном периоде после аортокоронарного шунтирования",

abstract = "Objective. To evaluate an effectiveness of intraoperative use of dexmedetomidine and clonidine for prevention of early postoperative neurocognitive disorders after coronary artery bypass grafting. Material and methods. A prospective study included 200 patients who underwent elective coronary artery bypass grafting under general combined anesthesia for the period from 2018 to 2019. Patients were randomized into 3 groups: group 1 (control) — 100 pa-tients, group 2 (clonidine) — 50 patients, and group 3 (dexmedetomidine) — 50 patients. Inclusion criteria were elective coronary artery bypass grafting, age 40—80 years, LV ejection fraction (Simpson{\textquoteright}s method) >50%, absence of dementia and mental illness. Clonidine and dexmedetomidine were injected after anesthesia induction and for 2 hours in early postoperative period. PND were evaluated using NuDESC (Nursing delirium screening scale) and SAGE (Self-Administrated Gerocognitive Exam) scales. Results. In the control group, delirium developed in 19% of patients, in clonidine group — 6%, dexmedetomidine group — 4% of patients (p=0,010 compared to the control group). Conclusion. Intraoperative use of clonidine and dexmedetomidine reduced the incidence of delirium in postoperative period.",

keywords = "Alpha-2 adrenergic receptor agonists, Clonidine, Coronary artery bypass grafting, Dexmedetomidine, Postoperative neurocognitive dysfunction",

author = "Balandina, {E. V.} and Volchkov, {V. A.} and Boyarkin, {A. A.} and Nefedov, {A. V.} and Kovalev, {S. V.}",

year = "2020",

doi = "10.17116/anaesthesiology202004142",

language = "русский",

volume = "2020",

pages = "42--47",

journal = "Russian Journal of Anesthesiology and Reanimatology /Anesteziologiya i Reanimatologiya",

issn = "0201-7563",

publisher = "Медицина",

number = "4",

}

RIS

TY - JOUR

T1 - клонидина и дексмедетомидина для профилактики нейрокогнитивных нарушений в ближайшем послеоперационном периоде после аортокоронарного шунтирования

AU - Balandina, E. V.

AU - Volchkov, V. A.

AU - Boyarkin, A. A.

AU - Nefedov, A. V.

AU - Kovalev, S. V.

PY - 2020

Y1 - 2020

N2 - Objective. To evaluate an effectiveness of intraoperative use of dexmedetomidine and clonidine for prevention of early postoperative neurocognitive disorders after coronary artery bypass grafting. Material and methods. A prospective study included 200 patients who underwent elective coronary artery bypass grafting under general combined anesthesia for the period from 2018 to 2019. Patients were randomized into 3 groups: group 1 (control) — 100 pa-tients, group 2 (clonidine) — 50 patients, and group 3 (dexmedetomidine) — 50 patients. Inclusion criteria were elective coronary artery bypass grafting, age 40—80 years, LV ejection fraction (Simpson’s method) >50%, absence of dementia and mental illness. Clonidine and dexmedetomidine were injected after anesthesia induction and for 2 hours in early postoperative period. PND were evaluated using NuDESC (Nursing delirium screening scale) and SAGE (Self-Administrated Gerocognitive Exam) scales. Results. In the control group, delirium developed in 19% of patients, in clonidine group — 6%, dexmedetomidine group — 4% of patients (p=0,010 compared to the control group). Conclusion. Intraoperative use of clonidine and dexmedetomidine reduced the incidence of delirium in postoperative period.

AB - Objective. To evaluate an effectiveness of intraoperative use of dexmedetomidine and clonidine for prevention of early postoperative neurocognitive disorders after coronary artery bypass grafting. Material and methods. A prospective study included 200 patients who underwent elective coronary artery bypass grafting under general combined anesthesia for the period from 2018 to 2019. Patients were randomized into 3 groups: group 1 (control) — 100 pa-tients, group 2 (clonidine) — 50 patients, and group 3 (dexmedetomidine) — 50 patients. Inclusion criteria were elective coronary artery bypass grafting, age 40—80 years, LV ejection fraction (Simpson’s method) >50%, absence of dementia and mental illness. Clonidine and dexmedetomidine were injected after anesthesia induction and for 2 hours in early postoperative period. PND were evaluated using NuDESC (Nursing delirium screening scale) and SAGE (Self-Administrated Gerocognitive Exam) scales. Results. In the control group, delirium developed in 19% of patients, in clonidine group — 6%, dexmedetomidine group — 4% of patients (p=0,010 compared to the control group). Conclusion. Intraoperative use of clonidine and dexmedetomidine reduced the incidence of delirium in postoperative period.

KW - Alpha-2 adrenergic receptor agonists

KW - Clonidine

KW - Coronary artery bypass grafting

KW - Dexmedetomidine

KW - Postoperative neurocognitive dysfunction

UR - http://www.scopus.com/inward/record.url?scp=85089953363&partnerID=8YFLogxK

U2 - 10.17116/anaesthesiology202004142

DO - 10.17116/anaesthesiology202004142

M3 - статья

AN - SCOPUS:85089953363

VL - 2020

SP - 42

EP - 47

JO - Russian Journal of Anesthesiology and Reanimatology /Anesteziologiya i Reanimatologiya

JF - Russian Journal of Anesthesiology and Reanimatology /Anesteziologiya i Reanimatologiya

SN - 0201-7563

IS - 4

ER -

ID: 75032935