Objective. To evaluate an effectiveness of intraoperative use of dexmedetomidine and clonidine for prevention of early postoperative neurocognitive disorders after coronary artery bypass grafting. Material and methods. A prospective study included 200 patients who underwent elective coronary artery bypass grafting under general combined anesthesia for the period from 2018 to 2019. Patients were randomized into 3 groups: group 1 (control) — 100 pa-tients, group 2 (clonidine) — 50 patients, and group 3 (dexmedetomidine) — 50 patients. Inclusion criteria were elective coronary artery bypass grafting, age 40—80 years, LV ejection fraction (Simpson’s method) >50%, absence of dementia and mental illness. Clonidine and dexmedetomidine were injected after anesthesia induction and for 2 hours in early postoperative period. PND were evaluated using NuDESC (Nursing delirium screening scale) and SAGE (Self-Administrated Gerocognitive Exam) scales. Results. In the control group, delirium developed in 19% of patients, in clonidine group — 6%, dexmedetomidine group — 4% of patients (p=0,010 compared to the control group). Conclusion. Intraoperative use of clonidine and dexmedetomidine reduced the incidence of delirium in postoperative period.