TY - JOUR

T1 - Современные представления о возможном участии алюминия в этиологии болезни Альцгеймера

AU - Чучина, Виктория Александровна

AU - Иваненко, Наталья Борисовна

AU - Губаль, Анна Романовна

AU - Ганеев, А.А.

AU - Зубакина, Е.А.

AU - Безручко, М.М.

AU - Литвинцев, Б.С.

PY - 2021/7/18

Y1 - 2021/7/18

N2 - The aim of the study was to investigate the possibility of using а concentration of aluminum as a marker of neurodegenerative diseases. Material and methods . To achieve this goal, there was carried out an analysis of literary origins from various databases, in particular Scopus and PubMed. Results . The analysis shows that by now there has been accumulated strong evidence that certain neurodegenerative diseases are associated with chronic exposure to low-dose of aluminum: in particular, Alzheimer's disease (AD); motor neuron disease or amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS) and a number of others. Conclusion . Thus, it can be assumed that the measurement of the concentration of Al in the blood plasma will make it possible to identify a group people with of high risk of AD, which will allow starting preventive treatment at the earliest stage of the disease. The capabilities of the existing methods of analysis: atomic absorption spectrometry with electrothermal atomization (GFAAS) and inductively coupled plasma mass spectrometry (ICP-MS) enable to solve this problem.

AB - The aim of the study was to investigate the possibility of using а concentration of aluminum as a marker of neurodegenerative diseases. Material and methods . To achieve this goal, there was carried out an analysis of literary origins from various databases, in particular Scopus and PubMed. Results . The analysis shows that by now there has been accumulated strong evidence that certain neurodegenerative diseases are associated with chronic exposure to low-dose of aluminum: in particular, Alzheimer's disease (AD); motor neuron disease or amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS) and a number of others. Conclusion . Thus, it can be assumed that the measurement of the concentration of Al in the blood plasma will make it possible to identify a group people with of high risk of AD, which will allow starting preventive treatment at the earliest stage of the disease. The capabilities of the existing methods of analysis: atomic absorption spectrometry with electrothermal atomization (GFAAS) and inductively coupled plasma mass spectrometry (ICP-MS) enable to solve this problem.

UR - https://www.mendeley.com/catalogue/2c078ed2-8cf5-332f-b80e-94bf94aa156d/

U2 - 10.36946/0869-7922-2021-29-3-10-15

DO - 10.36946/0869-7922-2021-29-3-10-15

M3 - статья

VL - 3

SP - 10

EP - 15

JO - ТОКСИКОЛОГИЧЕСКИЙ ВЕСТНИК

JF - ТОКСИКОЛОГИЧЕСКИЙ ВЕСТНИК

SN - 0869-7922

IS - 3

ER -