The experience of performing 44 partial nephrectomies using laparoscopic and lumboscopic approaches is presented. A comparative analysis of the effectiveness of different methods of hemostasis when performing nephron sparing interventions was conducted. It is shown that physical methods of hemostasis do not meet the necessary requirements, increasing warm ischemia time and the risk of intraoperative blood loss, and makes it difficult to visualize the boundaries of resection. Pilot study using histological assessment methods proved negative effects of high-frequency energy on parenchyma, which does not allow to recommend this method of hemostasis in nephron sparing surgery. We believe that currently ligature method in partial nephrectomy remains the only reliable and safe method for the achievement of final hemostasis.