Purpose. To look into the possibilities of perfusion computer tomography (PCT) in detection and preoperative staging of pancreatic adenocarcinoma, to determine and compare diagnostic effectiveness of computed tomography (CT) according to standart protocol and PCT. Materials and methods. The study included 161 patients from 28 to 96 years old (71, 8 ± 12,4 yr), who had verified pancreatic adenocarcinomas. Pancreatoduodenectomy was performed in 32 (19,8%) patients. All patients underwent CT according to standart protocol and PCT. Numerical tissue perfusion parameters of central and peripheral parts of tumors were estimated, color-coded maps were plotted and analyzed. The diagnostic effectiveness of CT according to standart protocol and PCT in preoperative staging of pancreatic adenocarcinoma were compared. Results. The diagnostic effectiveness of the perfusion program in comparison with the standard CT protocol appears to be higher in the detection and assessment of the local tumor spread, in the diagnosis of secondary lesions of regional lymph nodes. Conclusion. The perfusion program makes it possible to increase the diagnostic effiectiveness of computed tomography in the detection and assessment of the resectability of pancreatic adenocarcinoma, to determine the indications for pancreatoduodenectomy.