Purpose. The purpose of this article is to identify the most valuable methods of secondary adaptation management in the conditions of relocation for employees of IT companies. The study includes assessments and analysis of adaptation measures of three groups of companies: international companies that left Russia, international companies operating in Russia and Russian companies. Methodology. The methodological basis of the study is the general theory of adaptation, which considers it as a process triggered by new factors of external and internal environment, which has certain stages of development. As a mathematical and statistical apparatus used descriptive and variance analysis. To achieve the purpose of the study, a survey of 100 employees of IT companies with relocation experience was conducted. The usefulness of nine groups of practices was assessed: compensation for moving and living expenses; family support; cultural adaptation; social adaptation; domestic adaptation; medical support; assistance in legal, tax and migration issues; and “primary” adaptation measures. Findings. The analysis of the research results made it possible to identify the most effective, from the employees’ point of view, management practices and to assess their impact on the subjective perception of overcoming the anxiety stage of the adaptation process. Conclusions. The results made it possible to confirm the main hypotheses of the study. Firstly, employees of IT companies perceive relocation programs as meaningful tools for managing secondary adaptation, which positively influence the restoration of “pre-relocation” level of performance. Secondly, the assessment of the usefulness of certain practices of relocation programs is related to their focus on meeting the actual needs that arise when moving to a new environment. Value of results. The results of the study can be used by HR-managers and managers of IT-companies to develop a methodology of relocation policy and organize measures to adapt employees during relocation.