An electrochemical sensor with metal-organic frameworks based on copper (MOF-2(Cu)) was proposed to detect dopamine in the presence of paracetamol in microconcentrations. A change in the sensitivity of the obtained sensor was found out when the size of the crystallite of the studying compound changed. Metrological characteristics were obtained for this compound in voltammetric analysis of dopamine: linear range of 1-100 μM, LOD = 2.3 μM.