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Zn(OTf)2-catalyzed, microwave-promoted synthesis of 2-substituted 5-methyloxazoles from propargylic amides. / Safrygin, Alexander; Dar'in, Dmitry; Lukin, Alexei; Bakholdina, Anna; Sapegin, Alexander; Krasavin, Mikhail.

In: Tetrahedron Letters, Vol. 60, No. 11, 14.03.2019, p. 777-779.

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@article{fe7f08e4f9a34cd485e7f9ce24ee9207,
title = "Zn(OTf)2-catalyzed, microwave-promoted synthesis of 2-substituted 5-methyloxazoles from propargylic amides",
abstract = "The versatile conversion of propargylic amides to the respective 2-substituted 5-methyloxazoles was efficiently catalyzed by Zn(OTf)2 (5 mol%) under microwave irradiation in toluene. The method was applicable to a wide range of aliphatic, aromatic and heteroaromatic propargylic amides and thus represents a useful method which is complementary to the existing metal-catalyzed protocols, considering the ready availability of Zn(OTf)2.",
keywords = "Cyclization, Oxazoles, Propargylic amides, Zn(II) triflate, GOLD CATALYSIS, COMPLEXES, CYCLIZATION, OXAZOLINES",
author = "Alexander Safrygin and Dmitry Dar'in and Alexei Lukin and Anna Bakholdina and Alexander Sapegin and Mikhail Krasavin",
year = "2019",
month = mar,
day = "14",
doi = "10.1016/j.tetlet.2019.02.011",
language = "English",
volume = "60",
pages = "777--779",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Zn(OTf)2-catalyzed, microwave-promoted synthesis of 2-substituted 5-methyloxazoles from propargylic amides

AU - Safrygin, Alexander

AU - Dar'in, Dmitry

AU - Lukin, Alexei

AU - Bakholdina, Anna

AU - Sapegin, Alexander

AU - Krasavin, Mikhail

PY - 2019/3/14

Y1 - 2019/3/14

N2 - The versatile conversion of propargylic amides to the respective 2-substituted 5-methyloxazoles was efficiently catalyzed by Zn(OTf)2 (5 mol%) under microwave irradiation in toluene. The method was applicable to a wide range of aliphatic, aromatic and heteroaromatic propargylic amides and thus represents a useful method which is complementary to the existing metal-catalyzed protocols, considering the ready availability of Zn(OTf)2.

AB - The versatile conversion of propargylic amides to the respective 2-substituted 5-methyloxazoles was efficiently catalyzed by Zn(OTf)2 (5 mol%) under microwave irradiation in toluene. The method was applicable to a wide range of aliphatic, aromatic and heteroaromatic propargylic amides and thus represents a useful method which is complementary to the existing metal-catalyzed protocols, considering the ready availability of Zn(OTf)2.

KW - Cyclization

KW - Oxazoles

KW - Propargylic amides

KW - Zn(II) triflate

KW - GOLD CATALYSIS

KW - COMPLEXES

KW - CYCLIZATION

KW - OXAZOLINES

UR - http://www.scopus.com/inward/record.url?scp=85061139682&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/znotf-2-catalyzed-microwavepromoted-synthesis-2substituted-5methyloxazoles-propargylic-amides

U2 - 10.1016/j.tetlet.2019.02.011

DO - 10.1016/j.tetlet.2019.02.011

M3 - Article

AN - SCOPUS:85061139682

VL - 60

SP - 777

EP - 779

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 11

ER -

ID: 38490032