Research output: Contribution to journal › Article › peer-review
Zn(OTf)2-catalyzed, microwave-promoted synthesis of 2-substituted 5-methyloxazoles from propargylic amides. / Safrygin, Alexander; Dar'in, Dmitry; Lukin, Alexei; Bakholdina, Anna; Sapegin, Alexander; Krasavin, Mikhail.
In: Tetrahedron Letters, Vol. 60, No. 11, 14.03.2019, p. 777-779.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Zn(OTf)2-catalyzed, microwave-promoted synthesis of 2-substituted 5-methyloxazoles from propargylic amides
AU - Safrygin, Alexander
AU - Dar'in, Dmitry
AU - Lukin, Alexei
AU - Bakholdina, Anna
AU - Sapegin, Alexander
AU - Krasavin, Mikhail
PY - 2019/3/14
Y1 - 2019/3/14
N2 - The versatile conversion of propargylic amides to the respective 2-substituted 5-methyloxazoles was efficiently catalyzed by Zn(OTf)2 (5 mol%) under microwave irradiation in toluene. The method was applicable to a wide range of aliphatic, aromatic and heteroaromatic propargylic amides and thus represents a useful method which is complementary to the existing metal-catalyzed protocols, considering the ready availability of Zn(OTf)2.
AB - The versatile conversion of propargylic amides to the respective 2-substituted 5-methyloxazoles was efficiently catalyzed by Zn(OTf)2 (5 mol%) under microwave irradiation in toluene. The method was applicable to a wide range of aliphatic, aromatic and heteroaromatic propargylic amides and thus represents a useful method which is complementary to the existing metal-catalyzed protocols, considering the ready availability of Zn(OTf)2.
KW - Cyclization
KW - Oxazoles
KW - Propargylic amides
KW - Zn(II) triflate
KW - GOLD CATALYSIS
KW - COMPLEXES
KW - CYCLIZATION
KW - OXAZOLINES
UR - http://www.scopus.com/inward/record.url?scp=85061139682&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/znotf-2-catalyzed-microwavepromoted-synthesis-2substituted-5methyloxazoles-propargylic-amides
U2 - 10.1016/j.tetlet.2019.02.011
DO - 10.1016/j.tetlet.2019.02.011
M3 - Article
AN - SCOPUS:85061139682
VL - 60
SP - 777
EP - 779
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 11
ER -
ID: 38490032