Zn(OTf)2-catalyzed, microwave-promoted synthesis of 2-substituted 5-methyloxazoles from propargylic amides

Zn(OTf)₂-catalyzed, microwave-promoted synthesis of 2-substituted 5-methyloxazoles from propargylic amides

Research output: Contribution to journal › Article › peer-review

Laboratory of Chemical Pharmacology

DOI

https://doi.org/10.1016/j.tetlet.2019.02.011
Final published version

The versatile conversion of propargylic amides to the respective 2-substituted 5-methyloxazoles was efficiently catalyzed by Zn(OTf)₂ (5 mol%) under microwave irradiation in toluene. The method was applicable to a wide range of aliphatic, aromatic and heteroaromatic propargylic amides and thus represents a useful method which is complementary to the existing metal-catalyzed protocols, considering the ready availability of Zn(OTf)₂.

Original language	English
Pages (from-to)	777-779
Number of pages	3
Journal	Tetrahedron Letters
Volume	60
Issue number	11
DOIs	https://doi.org/10.1016/j.tetlet.2019.02.011
State	Published - 14 Mar 2019

Scopus subject areas

Drug Discovery
Biochemistry
Organic Chemistry

Research areas

Cyclization, Oxazoles, Propargylic amides, Zn(II) triflate, GOLD CATALYSIS, COMPLEXES, CYCLIZATION, OXAZOLINES

ID: 38490032