The increasing demand for wearable health trackers has sparked the development of innovative sensor technologies based on nanomaterials. Zinc oxide (ZnO) has emerged as a promising platform due to its low toxicity, piezoelectric and semiconductor properties, making it ideal for advanced sensor applications. In this study, we fabricate flexible pressure sensors employing ZnO nanowires encapsulated in a polymer matrix. The hydrothermal growth method allows for the simple fabrication of the devices. The sensors demonstrate both resistive and capacitive responses to an external load, enabling accurate pressure measurements. The sensors exhibit a wide measurement range of up to 2 MPa with a detection limit as low as 10 Pa and a sensitivity of up to 4 %⋅kPa−1. Additionally, we demonstrate the response to changes in temperature that can be distinguished from the response to a change in a mechanical load allowing for simultaneous pressure and temperature readings. Overall, our results suggest the prospects for these feasible, multifunctional flexible sensors to be utilized in portable health diagnostic systems and electronic skin.