Hydrohydrazination of a variety of propargylamides with BocNHNH2 under Zn(OTf)2 catalysis, unexpectedly, gave dihydro-1,2,4-triazines with a loss of the protecting group. The initial products can be efficiently aromatized in situ with K3[Fe(CN)6]. This provides a new entry into the medicinally important 1,2,4-triazine core.
| Original language | English |
|---|---|
| Pages (from-to) | 57956-57959 |
| Number of pages | 4 |
| Journal | RSC Advances |
| Volume | 6 |
| Issue number | 63 |
| DOIs | |
| State | Published - 2016 |
ID: 9433911