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When periphery matters: Enhanced reactivity of 8-oxa-1,4-dithiaspiro[4.5]decane-7,9-dione and 9-oxa-1,5-dithiaspiro[5.5]undecane-8,10-dione in the Castagnoli-Cushman reaction with imines

Research output: Contribution to journal › Article › peer-review

DOI

https://doi.org/10.1016/j.tetlet.2020.152658
Final published version

8-Oxa-1,4-dithiaspiro[4.5]decane-7,9-dione and 9-oxa-1,5-dithiaspiro[5.5]undecane-8,10-dione, cyclic anhydrides formed in situ from the respective dicarboxylic acids in the presence of acetic anhydride, possess an enhanced reactivity and display a broad substrate scope in the Castagnoli-Cushman reaction with imines.

Original language	English
Article number	152658
Journal	Tetrahedron Letters
Volume	61
Issue number	52
DOIs	https://doi.org/10.1016/j.tetlet.2020.152658
State	Published - 24 Dec 2020

Research areas

Castagnoli-Cushman reaction, Cyclic anhydride, Dicarboxylic acids, Enol form, In situ cyclodehydration, Sulfur atom vacant d-orbitals

Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

ID: 71395306