In the present research, the low-temperature molar heat capacity, C_p,m°, of C₆₀ – L-lysine derivative was measured using adiabatic calorimetry from T = 13 K to T = 326 K. The respective molar third law entropy at T = 298.15 K, S_m°, was calculated giving (1110 ± 3) J·K⁻¹·mol⁻¹ for C₆₀ – L-lysine derivative. Smoothed C_p,m°(T) values between T → 0 K and 320 K are presented along with the values for S_m° and the functions [H_m°(T) – H_m°(0)] and [G_m°(T) – H_m°(0)]. The standard molar entropy of formation, Δ_fS_m°, at T = 298.15 K was calculated for the compound under study in the crystalline state giving −1916 ± 5 J·K⁻¹·mol⁻¹. The complex thermal analysis of the C₆₀-Lys crystallohydrate was performed from T = 300 to T = 1323 K.