The TAAR5 agonist α-NETA causes dyskinesia in mice

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The TAAR5 agonist α-NETA causes dyskinesia in mice. / Aleksandrov, A.A.; Polyakova, N.V.; Vinogradova, E.P.; Gainetdinov, R.R.; Knyazeva, V.M.

In: Neuroscience Letters, Vol. 704, 21.06.2019, p. 208-211.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{c96d136ec63d4ab3991407b556de47b6,

title = "The TAAR5 agonist α-NETA causes dyskinesia in mice",

abstract = "It is known that trace amine-associated receptor 5 (TAAR5) is expressed in various regions of the central nervous system. However, very limited information is available on the behavioral effects of TAAR5 activation and the TAAR5 functional role, in general. We studied the effect of TAAR5 agonist (2-(alpha-naphthoyl) ethyltrimethylammonium iodide) systemic administration on animal behavior. The study was performed on male C57BL/6 mice. It was observed that α-NETA in 10 mg/kg dose caused specific impairment of motor behavior, similar to the manifestations of tardive dyskinesia in humans. It can be assumed that trace amines and TAAR5 may be involved in the human tardive dyskinesia pathogenesis.",

keywords = "Trace amines, Trace amine-associated receptors, TAAR5, α-NETA, Dyskinesia, Tardive dyskinesia, alpha-NETA, AMINE-ASSOCIATED RECEPTORS, TRACE AMINES, MODEL, AMPHETAMINE",

author = "A.A. Aleksandrov and N.V. Polyakova and E.P. Vinogradova and R.R. Gainetdinov and V.M. Knyazeva",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = jun,

day = "21",

doi = "10.1016/j.neulet.2019.04.028",

language = "English",

volume = "704",

pages = "208--211",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The TAAR5 agonist α-NETA causes dyskinesia in mice

AU - Aleksandrov, A.A.

AU - Polyakova, N.V.

AU - Vinogradova, E.P.

AU - Gainetdinov, R.R.

AU - Knyazeva, V.M.

PY - 2019/6/21

Y1 - 2019/6/21

N2 - It is known that trace amine-associated receptor 5 (TAAR5) is expressed in various regions of the central nervous system. However, very limited information is available on the behavioral effects of TAAR5 activation and the TAAR5 functional role, in general. We studied the effect of TAAR5 agonist (2-(alpha-naphthoyl) ethyltrimethylammonium iodide) systemic administration on animal behavior. The study was performed on male C57BL/6 mice. It was observed that α-NETA in 10 mg/kg dose caused specific impairment of motor behavior, similar to the manifestations of tardive dyskinesia in humans. It can be assumed that trace amines and TAAR5 may be involved in the human tardive dyskinesia pathogenesis.

AB - It is known that trace amine-associated receptor 5 (TAAR5) is expressed in various regions of the central nervous system. However, very limited information is available on the behavioral effects of TAAR5 activation and the TAAR5 functional role, in general. We studied the effect of TAAR5 agonist (2-(alpha-naphthoyl) ethyltrimethylammonium iodide) systemic administration on animal behavior. The study was performed on male C57BL/6 mice. It was observed that α-NETA in 10 mg/kg dose caused specific impairment of motor behavior, similar to the manifestations of tardive dyskinesia in humans. It can be assumed that trace amines and TAAR5 may be involved in the human tardive dyskinesia pathogenesis.

KW - Trace amines

KW - Trace amine-associated receptors

KW - TAAR5

KW - α-NETA

KW - Dyskinesia

KW - Tardive dyskinesia

KW - alpha-NETA

KW - AMINE-ASSOCIATED RECEPTORS

KW - TRACE AMINES

KW - MODEL

KW - AMPHETAMINE

UR - http://www.scopus.com/inward/record.url?scp=85064240754&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2019.04.028

DO - 10.1016/j.neulet.2019.04.028

M3 - Article

VL - 704

SP - 208

EP - 211

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

ER -

ID: 40906151