The study is devoted to the detailed investigation of the ipso-chlorination reaction of calixarenes and search of an optimal combination of chlorinating reagents. This factor was varied in a number of experiments. It was established that the presence of sulphuryl chloride and the acidic proton is a necessary condition for successful ipso-chlorination of calix[4]arenes. The addition of any of phosphorus chlorides accelerates reaction speed and increases process yield. So the most promising chlorination mixture was that SO2Cl2 (4 eq.), POCl3 (1 eq.) and glacial acetic acid (1 eq.) which provided 64% yield of the desired compound after two days of the experiment.

Original languageEnglish
Title of host publicationModern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2019
Subtitle of host publicationProceedings of the III International Conference
EditorsGrigory V. Zyryanov, Sougata Santra, Leila K. Sadieva
PublisherAmerican Institute of Physics
ISBN (Electronic)9780735440104
DOIs
StatePublished - 4 Nov 2020
Externally publishedYes
Event3rd International Conference on Modern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2019 - Yekaterinburg, Russian Federation
Duration: 13 Nov 201916 Nov 2019

Publication series

NameAIP Conference Proceedings
Volume2280
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Conference on Modern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2019
Country/TerritoryRussian Federation
CityYekaterinburg
Period13/11/1916/11/19

    Scopus subject areas

  • Physics and Astronomy(all)

ID: 84915709