Final published version
The study is devoted to the detailed investigation of the ipso-chlorination reaction of calixarenes and search of an optimal combination of chlorinating reagents. This factor was varied in a number of experiments. It was established that the presence of sulphuryl chloride and the acidic proton is a necessary condition for successful ipso-chlorination of calix[4]arenes. The addition of any of phosphorus chlorides accelerates reaction speed and increases process yield. So the most promising chlorination mixture was that SO2Cl2 (4 eq.), POCl3 (1 eq.) and glacial acetic acid (1 eq.) which provided 64% yield of the desired compound after two days of the experiment.
Original language | English |
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Title of host publication | Modern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2019 |
Subtitle of host publication | Proceedings of the III International Conference |
Editors | Grigory V. Zyryanov, Sougata Santra, Leila K. Sadieva |
Publisher | American Institute of Physics |
ISBN (Electronic) | 9780735440104 |
DOIs | |
State | Published - 4 Nov 2020 |
Externally published | Yes |
Event | 3rd International Conference on Modern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2019 - Yekaterinburg, Russian Federation Duration: 13 Nov 2019 → 16 Nov 2019 |
Name | AIP Conference Proceedings |
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Volume | 2280 |
ISSN (Print) | 0094-243X |
ISSN (Electronic) | 1551-7616 |
Conference | 3rd International Conference on Modern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2019 |
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Country/Territory | Russian Federation |
City | Yekaterinburg |
Period | 13/11/19 → 16/11/19 |
ID: 84915709