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The Effect of Quercetin on Metabolism and Behavioral Responses in Mice with Normal and Impaired Leptin Reception. / Apryatin, S. A.; Shipelin, V. A.; Trusov, N. V.; Mzhel’skaya, K. V.; Kirbaeva, N. V.; Soto, J. S.; Riger, N. A.; Gmoshinski, I. V.

In: Biology Bulletin, Vol. 47, No. 4, 01.07.2020, p. 407-416.

Research output: Contribution to journal › Article › peer-review

Harvard

Apryatin, SA, Shipelin, VA, Trusov, NV, Mzhel’skaya, KV, Kirbaeva, NV, Soto, JS, Riger, NA & Gmoshinski, IV 2020, 'The Effect of Quercetin on Metabolism and Behavioral Responses in Mice with Normal and Impaired Leptin Reception', Biology Bulletin, vol. 47, no. 4, pp. 407-416. https://doi.org/10.1134/S1062359020040020

APA

Apryatin, S. A., Shipelin, V. A., Trusov, N. V., Mzhel’skaya, K. V., Kirbaeva, N. V., Soto, J. S., Riger, N. A., & Gmoshinski, I. V. (2020). The Effect of Quercetin on Metabolism and Behavioral Responses in Mice with Normal and Impaired Leptin Reception. Biology Bulletin, 47(4), 407-416. https://doi.org/10.1134/S1062359020040020

Vancouver

Apryatin SA, Shipelin VA, Trusov NV, Mzhel’skaya KV, Kirbaeva NV, Soto JS et al. The Effect of Quercetin on Metabolism and Behavioral Responses in Mice with Normal and Impaired Leptin Reception. Biology Bulletin. 2020 Jul 1;47(4):407-416. https://doi.org/10.1134/S1062359020040020

Author

Apryatin, S. A. ; Shipelin, V. A. ; Trusov, N. V. ; Mzhel’skaya, K. V. ; Kirbaeva, N. V. ; Soto, J. S. ; Riger, N. A. ; Gmoshinski, I. V. / The Effect of Quercetin on Metabolism and Behavioral Responses in Mice with Normal and Impaired Leptin Reception. In: Biology Bulletin. 2020 ; Vol. 47, No. 4. pp. 407-416.

BibTeX

@article{34dd77e02fad4de897bd47e022b5ed27,
title = "The Effect of Quercetin on Metabolism and Behavioral Responses in Mice with Normal and Impaired Leptin Reception",
abstract = "Abstract: We studied the effects of quercetin (Q) on the behavioral responses and integral and metabolic indices in male db/db mice genetically predisposed to obesity and C57Bl/6J mice fed a diet with an excessive energy value. We examined forepaw grip strength, exploratory activity, anxiety, and short-term memory, as well as integral and biochemical indices, and the contents of leptin, ghrelin, and IL-10. We found differences between two models of obesity in the integral and biochemical indices and behavioral responses to Q treatment. In the db/db mice, they were associated with knockout of the Lepr gene encoding the leptin receptor, which prevented the neurotropic and regulatory functions of leptin. These effects of Q detected should be considered when justifying the dose and timing of this nutraceutical in clinical practice.",
author = "Apryatin, {S. A.} and Shipelin, {V. A.} and Trusov, {N. V.} and Mzhel{\textquoteright}skaya, {K. V.} and Kirbaeva, {N. V.} and Soto, {J. S.} and Riger, {N. A.} and Gmoshinski, {I. V.}",
year = "2020",
month = jul,
day = "1",
doi = "10.1134/S1062359020040020",
language = "English",
volume = "47",
pages = "407--416",
journal = "Biology Bulletin",
issn = "1062-3590",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "4",

}

RIS

TY - JOUR

T1 - The Effect of Quercetin on Metabolism and Behavioral Responses in Mice with Normal and Impaired Leptin Reception

AU - Apryatin, S. A.

AU - Shipelin, V. A.

AU - Trusov, N. V.

AU - Mzhel’skaya, K. V.

AU - Kirbaeva, N. V.

AU - Soto, J. S.

AU - Riger, N. A.

AU - Gmoshinski, I. V.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Abstract: We studied the effects of quercetin (Q) on the behavioral responses and integral and metabolic indices in male db/db mice genetically predisposed to obesity and C57Bl/6J mice fed a diet with an excessive energy value. We examined forepaw grip strength, exploratory activity, anxiety, and short-term memory, as well as integral and biochemical indices, and the contents of leptin, ghrelin, and IL-10. We found differences between two models of obesity in the integral and biochemical indices and behavioral responses to Q treatment. In the db/db mice, they were associated with knockout of the Lepr gene encoding the leptin receptor, which prevented the neurotropic and regulatory functions of leptin. These effects of Q detected should be considered when justifying the dose and timing of this nutraceutical in clinical practice.

AB - Abstract: We studied the effects of quercetin (Q) on the behavioral responses and integral and metabolic indices in male db/db mice genetically predisposed to obesity and C57Bl/6J mice fed a diet with an excessive energy value. We examined forepaw grip strength, exploratory activity, anxiety, and short-term memory, as well as integral and biochemical indices, and the contents of leptin, ghrelin, and IL-10. We found differences between two models of obesity in the integral and biochemical indices and behavioral responses to Q treatment. In the db/db mice, they were associated with knockout of the Lepr gene encoding the leptin receptor, which prevented the neurotropic and regulatory functions of leptin. These effects of Q detected should be considered when justifying the dose and timing of this nutraceutical in clinical practice.

UR - http://www.scopus.com/inward/record.url?scp=85088831540&partnerID=8YFLogxK

U2 - 10.1134/S1062359020040020

DO - 10.1134/S1062359020040020

M3 - Article

AN - SCOPUS:85088831540

VL - 47

SP - 407

EP - 416

JO - Biology Bulletin

JF - Biology Bulletin

SN - 1062-3590

IS - 4

ER -

ID: 115015929