Research output: Contribution to journal › Article › peer-review
The Effect of Quercetin on Metabolism and Behavioral Responses in Mice with Normal and Impaired Leptin Reception. / Apryatin, S. A.; Shipelin, V. A.; Trusov, N. V.; Mzhel’skaya, K. V.; Kirbaeva, N. V.; Soto, J. S.; Riger, N. A.; Gmoshinski, I. V.
In: Biology Bulletin, Vol. 47, No. 4, 01.07.2020, p. 407-416.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - The Effect of Quercetin on Metabolism and Behavioral Responses in Mice with Normal and Impaired Leptin Reception
AU - Apryatin, S. A.
AU - Shipelin, V. A.
AU - Trusov, N. V.
AU - Mzhel’skaya, K. V.
AU - Kirbaeva, N. V.
AU - Soto, J. S.
AU - Riger, N. A.
AU - Gmoshinski, I. V.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Abstract: We studied the effects of quercetin (Q) on the behavioral responses and integral and metabolic indices in male db/db mice genetically predisposed to obesity and C57Bl/6J mice fed a diet with an excessive energy value. We examined forepaw grip strength, exploratory activity, anxiety, and short-term memory, as well as integral and biochemical indices, and the contents of leptin, ghrelin, and IL-10. We found differences between two models of obesity in the integral and biochemical indices and behavioral responses to Q treatment. In the db/db mice, they were associated with knockout of the Lepr gene encoding the leptin receptor, which prevented the neurotropic and regulatory functions of leptin. These effects of Q detected should be considered when justifying the dose and timing of this nutraceutical in clinical practice.
AB - Abstract: We studied the effects of quercetin (Q) on the behavioral responses and integral and metabolic indices in male db/db mice genetically predisposed to obesity and C57Bl/6J mice fed a diet with an excessive energy value. We examined forepaw grip strength, exploratory activity, anxiety, and short-term memory, as well as integral and biochemical indices, and the contents of leptin, ghrelin, and IL-10. We found differences between two models of obesity in the integral and biochemical indices and behavioral responses to Q treatment. In the db/db mice, they were associated with knockout of the Lepr gene encoding the leptin receptor, which prevented the neurotropic and regulatory functions of leptin. These effects of Q detected should be considered when justifying the dose and timing of this nutraceutical in clinical practice.
UR - http://www.scopus.com/inward/record.url?scp=85088831540&partnerID=8YFLogxK
U2 - 10.1134/S1062359020040020
DO - 10.1134/S1062359020040020
M3 - Article
AN - SCOPUS:85088831540
VL - 47
SP - 407
EP - 416
JO - Biology Bulletin
JF - Biology Bulletin
SN - 1062-3590
IS - 4
ER -
ID: 115015929