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The CRHR1 gene : A marker for suicidality in depressed males exposed to low stress. / Wasserman, D.; Sokolowski, M.; Rozanov, V.; Wasserman, J.

In: Genes, Brain and Behavior, Vol. 7, No. 1, 01.02.2008, p. 14-19.

Research output: Contribution to journal › Article › peer-review

Harvard

Wasserman, D, Sokolowski, M, Rozanov, V & Wasserman, J 2008, 'The CRHR1 gene: A marker for suicidality in depressed males exposed to low stress', Genes, Brain and Behavior, vol. 7, no. 1, pp. 14-19. https://doi.org/10.1111/j.1601-183X.2007.00310.x

APA

Wasserman, D., Sokolowski, M., Rozanov, V., & Wasserman, J. (2008). The CRHR1 gene: A marker for suicidality in depressed males exposed to low stress. Genes, Brain and Behavior, 7(1), 14-19. https://doi.org/10.1111/j.1601-183X.2007.00310.x

Vancouver

Wasserman D, Sokolowski M, Rozanov V, Wasserman J. The CRHR1 gene: A marker for suicidality in depressed males exposed to low stress. Genes, Brain and Behavior. 2008 Feb 1;7(1):14-19. https://doi.org/10.1111/j.1601-183X.2007.00310.x

Author

Wasserman, D. ; Sokolowski, M. ; Rozanov, V. ; Wasserman, J. / The CRHR1 gene : A marker for suicidality in depressed males exposed to low stress. In: Genes, Brain and Behavior. 2008 ; Vol. 7, No. 1. pp. 14-19.

BibTeX

@article{9c68db1c394f44f590d741f938eb6ba7,
title = "The CRHR1 gene: A marker for suicidality in depressed males exposed to low stress",
abstract = "The risk of suicide, which causes about 1 million deaths each year, is considered to augment as the levels of stress increases. Dysregulation in the stress response of the hypothalamic-pituitary-adrenocortical (HPA) axis, involving the corticotrophin-releasing hormone (CRH) and its main receptor (CRHR1), is associated with depression, frequent among suicidal males. Here we have analyzed single nucleotide polymorphisms (SNPs) in these genes, in family trios with suicide attempter offspring (n = 542), by using the transmission disequilibrium test both in a two-staged screening/replication sample design and in detailed reanalysis in the entire sample. Stratification based on the levels of lifetime stress showed reproducible association and linkage of an SNP in the CRHR1 gene (rs4792887) to suicide attempters exposed to low levels of stress (P = 0.002), among whom most males were depressed (P = 0.001). The identified allele may represent a part of the genetic susceptibility for suicidality by increasing HPA axis activity upon exposure to low levels of stress.",
keywords = "CRHR1 gene, Depression, Male, Polymorphism, Stress, Suicidality",
author = "D. Wasserman and M. Sokolowski and V. Rozanov and J. Wasserman",
year = "2008",
month = feb,
day = "1",
doi = "10.1111/j.1601-183X.2007.00310.x",
language = "English",
volume = "7",
pages = "14--19",
journal = "Genes, Brain and Behavior",
issn = "1601-1848",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - The CRHR1 gene

T2 - A marker for suicidality in depressed males exposed to low stress

AU - Wasserman, D.

AU - Sokolowski, M.

AU - Rozanov, V.

AU - Wasserman, J.

PY - 2008/2/1

Y1 - 2008/2/1

N2 - The risk of suicide, which causes about 1 million deaths each year, is considered to augment as the levels of stress increases. Dysregulation in the stress response of the hypothalamic-pituitary-adrenocortical (HPA) axis, involving the corticotrophin-releasing hormone (CRH) and its main receptor (CRHR1), is associated with depression, frequent among suicidal males. Here we have analyzed single nucleotide polymorphisms (SNPs) in these genes, in family trios with suicide attempter offspring (n = 542), by using the transmission disequilibrium test both in a two-staged screening/replication sample design and in detailed reanalysis in the entire sample. Stratification based on the levels of lifetime stress showed reproducible association and linkage of an SNP in the CRHR1 gene (rs4792887) to suicide attempters exposed to low levels of stress (P = 0.002), among whom most males were depressed (P = 0.001). The identified allele may represent a part of the genetic susceptibility for suicidality by increasing HPA axis activity upon exposure to low levels of stress.

AB - The risk of suicide, which causes about 1 million deaths each year, is considered to augment as the levels of stress increases. Dysregulation in the stress response of the hypothalamic-pituitary-adrenocortical (HPA) axis, involving the corticotrophin-releasing hormone (CRH) and its main receptor (CRHR1), is associated with depression, frequent among suicidal males. Here we have analyzed single nucleotide polymorphisms (SNPs) in these genes, in family trios with suicide attempter offspring (n = 542), by using the transmission disequilibrium test both in a two-staged screening/replication sample design and in detailed reanalysis in the entire sample. Stratification based on the levels of lifetime stress showed reproducible association and linkage of an SNP in the CRHR1 gene (rs4792887) to suicide attempters exposed to low levels of stress (P = 0.002), among whom most males were depressed (P = 0.001). The identified allele may represent a part of the genetic susceptibility for suicidality by increasing HPA axis activity upon exposure to low levels of stress.

KW - CRHR1 gene

KW - Depression

KW - Male

KW - Polymorphism

KW - Stress

KW - Suicidality

UR - http://www.scopus.com/inward/record.url?scp=38349050315&partnerID=8YFLogxK

U2 - 10.1111/j.1601-183X.2007.00310.x

DO - 10.1111/j.1601-183X.2007.00310.x

M3 - Article

C2 - 17376150

AN - SCOPUS:38349050315

VL - 7

SP - 14

EP - 19

JO - Genes, Brain and Behavior

JF - Genes, Brain and Behavior

SN - 1601-1848

IS - 1

ER -

ID: 42217428