The Soviet Foreign Policy towards Latin American countries in the inter-war period and the Communist International’s activities in those regions were interconnected for years and sometimes it was impossible to separate them. However, there was a slight difference in attitudes taken by Moscow toward Latin American countries, and while the Mexican case was more important for both the USSR and the Comintern from the political, revolutionary and geopolitical perspective, the Argentinean case was, rather, an example of coexistence due to economic needs. For years, this dualism in the Soviet Foreign policy was helping Moscow expand its influence, but was at the same time bringing constant disagreements in its relations with Latin American governments. This chapter studies the international political relations of Mexico, Argentina and Uruguay with the Soviet Union which impacted the political and economic relations for decades.