tert-Butyl 3-Diazo-2-oxopyrrolidine-1-carboxylate – A New Reagent for Introduction of the 2-Oxopyrrolidin-3-yl Motif via RhII-Catalyzed X–H Insertion Reactions

tert-Butyl 3-Diazo-2-oxopyrrolidine-1-carboxylate – A New Reagent for Introduction of the 2-Oxopyrrolidin-3-yl Motif via Rh^II-Catalyzed X–H Insertion Reactions

Research output: Contribution to journal › Article › peer-review

DOI

https://doi.org/10.1002/ejoc.202000067
Final published version

tert-Butyl 3-diazo-2-oxopyrrolidine-1-carboxylate synthesized on multigram scale has been employed to introduce a privileged NH-2-pyrrolidone moiety via oxygen, sulfur and nitrogen atom to partner molecules via Rh^II-catalyzed X–H insertion followed by Boc group removal. Further manipulation of pyrrolidine moiety has been exemplified.

Original language	English
Pages (from-to)	3013-3018
Number of pages	6
Journal	European Journal of Organic Chemistry
Volume	2020
Issue number	20
DOIs	https://doi.org/10.1002/ejoc.202000067
State	Published - 29 May 2020

Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry

Research areas

2-pyrrolidone, Diazo transfer, Lactam reduction, Privileged structures, RhII-catalyzed X–H insertion, RhII-catalyzed X-H insertion

ID: 52504934