Systematic evaluation of the population-level effects of alternative treatment strategies on the basic reproduction number

Research output: Contribution to journal › Article › peer-review

Department of Computational Methods in Continuum Mechanics

DOI

https://doi.org/10.1016/j.jtbi.2018.11.029
Final published version

Dmitry Gromov
Ingo Bulla
Ethan O. Romero-Severson

An approach to estimate the influence of the treatment-type controls on the basic reproduction number, R-0, is proposed and elaborated. The presented approach allows one to estimate the effect of a given treatment strategy or to compare a number of different treatment strategies on the basic reproduction number. All our results are valid for sufficiently small values of the control. However, in many cases it is possible to extend this analysis to larger values of the control as was illustrated by examples. (C) 2018 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	381-390
Number of pages	10
Journal	Journal of Theoretical Biology
Volume	462
DOIs	https://doi.org/10.1016/j.jtbi.2018.11.029
State	Published - 7 Feb 2019

Research areas

Disease control, Basic reproduction number, Treatment, Compartmental epidemic model, Next generation matrix, MODEL, COINFECTION, DYNAMICS, HIV, R-0

Scopus subject areas

Agricultural and Biological Sciences(all)
Applied Mathematics
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Statistics and Probability
Modelling and Simulation

ID: 36612455