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Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon. / Бархатова, Дарина Дадашевна; Жуковский, Даниил Дмитриевич; Heim, Christopher; Maiwald, Samuel; Hartmann, Marcus D.; Красавин, Михаил Юрьевич.

In: Mendeleev Communications, Vol. 32, No. 6, 01.11.2022, p. 747-749.

Research output: Contribution to journal › Article › peer-review

Harvard

Бархатова, ДД, Жуковский, ДД, Heim, C, Maiwald, S, Hartmann, MD & Красавин, МЮ 2022, 'Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon', Mendeleev Communications, vol. 32, no. 6, pp. 747-749. https://doi.org/10.1016/j.mencom.2022.11.013

APA

Бархатова, Д. Д., Жуковский, Д. Д., Heim, C., Maiwald, S., Hartmann, M. D., & Красавин, М. Ю. (2022). Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon. Mendeleev Communications, 32(6), 747-749. https://doi.org/10.1016/j.mencom.2022.11.013

Vancouver

Бархатова ДД, Жуковский ДД, Heim C, Maiwald S, Hartmann MD, Красавин МЮ. Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon. Mendeleev Communications. 2022 Nov 1;32(6):747-749. https://doi.org/10.1016/j.mencom.2022.11.013

Author

Бархатова, Дарина Дадашевна ; Жуковский, Даниил Дмитриевич ; Heim, Christopher ; Maiwald, Samuel ; Hartmann, Marcus D. ; Красавин, Михаил Юрьевич. / Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon. In: Mendeleev Communications. 2022 ; Vol. 32, No. 6. pp. 747-749.

BibTeX

@article{ccede16194874f969bd940f555dea7e3,
title = "Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon",
abstract = "The glutarimide moiety, common in many immuno-modulatory drugs, was decorated with lactam and diamide side chains via two variants of the Ugi reaction, namely, with isocyanide, aldehyde and acid or with isocyanide and oxo acid. The resulting diastereomerically pure compounds were evaluated for their affinity towards the E3 ubiquitin ligase substrate receptor Cereblon.",
keywords = "2-aminoglutarimide, Cereblon, E3 ubiquitin ligase, Ugi reaction, immunomodulatory drugs, isocyanides, oxo acids",
author = "Бархатова, {Дарина Дадашевна} and Жуковский, {Даниил Дмитриевич} and Christopher Heim and Samuel Maiwald and Hartmann, {Marcus D.} and Красавин, {Михаил Юрьевич}",
note = "Publisher Copyright: {\textcopyright} 2022",
year = "2022",
month = nov,
day = "1",
doi = "10.1016/j.mencom.2022.11.013",
language = "English",
volume = "32",
pages = "747--749",
journal = "Mendeleev Communications",
issn = "0959-9436",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon

AU - Бархатова, Дарина Дадашевна

AU - Жуковский, Даниил Дмитриевич

AU - Heim, Christopher

AU - Maiwald, Samuel

AU - Hartmann, Marcus D.

AU - Красавин, Михаил Юрьевич

N1 - Publisher Copyright: © 2022

PY - 2022/11/1

Y1 - 2022/11/1

N2 - The glutarimide moiety, common in many immuno-modulatory drugs, was decorated with lactam and diamide side chains via two variants of the Ugi reaction, namely, with isocyanide, aldehyde and acid or with isocyanide and oxo acid. The resulting diastereomerically pure compounds were evaluated for their affinity towards the E3 ubiquitin ligase substrate receptor Cereblon.

AB - The glutarimide moiety, common in many immuno-modulatory drugs, was decorated with lactam and diamide side chains via two variants of the Ugi reaction, namely, with isocyanide, aldehyde and acid or with isocyanide and oxo acid. The resulting diastereomerically pure compounds were evaluated for their affinity towards the E3 ubiquitin ligase substrate receptor Cereblon.

KW - 2-aminoglutarimide

KW - Cereblon

KW - E3 ubiquitin ligase

KW - Ugi reaction

KW - immunomodulatory drugs

KW - isocyanides

KW - oxo acids

UR - http://www.scopus.com/inward/record.url?scp=85143165156&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/a9c89f37-aadf-31b3-af5b-312e95af5fb3/

U2 - 10.1016/j.mencom.2022.11.013

DO - 10.1016/j.mencom.2022.11.013

M3 - Article

VL - 32

SP - 747

EP - 749

JO - Mendeleev Communications

JF - Mendeleev Communications

SN - 0959-9436

IS - 6

ER -

ID: 100705686