Reaction of N-arylacetoacetamides with aromatic aldehydes in the presence of piperidine in ethanol afforded N,N′,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides. The latter reacted with p-toluidine leading to the formation of dehydration products. Reactions of N,N′,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate and cyanoacetic acid hydrazide gave rise to tetrahydroindazoles. Some of the obtained compounds showed antimicrobial activity.